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微创二尖瓣修复术的短期疗效:倾向评分匹配比较

Short-term outcomes of minimally invasive mitral valve repair: a propensity-matched comparison.

作者信息

Wang Qing, Xi Wang, Gao Yang, Shen Hua, Min Jie, Yang Jie, Le Shiguan, Zhang Yufeng, Wang Zhinong

机构信息

Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.

出版信息

Interact Cardiovasc Thorac Surg. 2018 May 1;26(5):805-812. doi: 10.1093/icvts/ivx402.

Abstract

OBJECTIVES

We aimed to investigate the effect of minimally invasive mitral valve repair on early pulmonary function and haemodynamics, as well as its short-term efficacy.

METHODS

From March 2012 to July 2015, 78 cases of minimally invasive mitral valve repair and 89 cases of conventional mitral valve repair were included in this study, with 67 well-matched pairs of patients identified by a propensity score matching, who were divided into the conventional sternotomy group and the right minithoracotomy group (the RT group).

RESULTS

The in-hospital mortality was similar between the 2 groups (3.0% vs 1.5%, P = 1.000). Both cross-clamp time and bypass time were higher in the RT group (P < 0.001), whereas drainage amount, blood transfusion and length of intensive care unit stay were higher in the conventional sternotomy group (P < 0.001). There was not much discrepancy in pulmonary function between the 2 groups, except that partial pressure of O2 in arterial blood (PaO2)/fraction of inspired oxygen (FiO2) in the RT group was significantly lower than that in the conventional sternotomy group 0, 4 and 8 h after surgery (P < 0.05), whereas the extravascular lung water index (ELWI), pulmonary vascular permeability index (PVPI) and alveolar-arterial PO2 difference (PA-aO2) of the RT group was higher (P < 0.05). We found no disparity in haemodynamics (P > 0.05), incidence of complications (P > 0.05) and short-term recurrence between the 2 groups (P = 0.7697).

CONCLUSIONS

When compared with the median sternotomy approach, the RT approach shows comparable results in short-term efficacy and safety. On relatively increasing cardiopulmonary bypass time and operation time, the RT approach shortens the patient's intensive care unit stay and reduces the need for blood transfusion. Pulmonary function may be affected shortly post-surgery in the RT approach, with insignificant difference in haemodynamics.

摘要

目的

我们旨在研究微创二尖瓣修复术对早期肺功能和血流动力学的影响及其短期疗效。

方法

2012年3月至2015年7月,本研究纳入78例微创二尖瓣修复术患者和89例传统二尖瓣修复术患者,通过倾向评分匹配确定67对匹配良好的患者,分为传统胸骨切开术组和右胸小切口组(RT组)。

结果

两组患者的院内死亡率相似(3.0%对1.5%,P = 1.000)。RT组的主动脉阻断时间和体外循环时间均较长(P < 0.001),而传统胸骨切开术组的引流量、输血量和重症监护病房住院时间较长(P < 0.001)。两组患者的肺功能差异不大,只是RT组术后0、4和8小时的动脉血氧分压(PaO2)/吸入氧分数(FiO2)明显低于传统胸骨切开术组(P < 0.05),而RT组的血管外肺水指数(ELWI)、肺血管通透性指数(PVPI)和肺泡 - 动脉血氧分压差(PA - aO2)较高(P < 0.05)。我们发现两组在血流动力学(P > 0.05)、并发症发生率(P > 0.05)和短期复发率方面无差异(P = 0.7697)。

结论

与正中胸骨切开术相比,RT入路在短期疗效和安全性方面显示出相当的结果。在相对增加体外循环时间和手术时间的情况下,RT入路缩短了患者的重症监护病房住院时间并减少了输血需求。RT入路术后短期内肺功能可能会受到影响,血流动力学方面差异不显著。

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