Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Cell Stem Cell. 2018 Jan 4;22(1):5-7. doi: 10.1016/j.stem.2017.12.014.
The bone marrow (BM) niche is a complex microenvironment that supports healthy hematopoietic stem cells (HSCs) throughout life. In this issue of Cell Stem Cell, Duarte et al. (2018) reveal the spatio-temporal progress of leukemic cells as they invade and occupy the niche, ultimately outcompeting native HSCs.
骨髓（BM）龛是一个复杂的微环境，终生支持健康的造血干细胞（HSCs）。在本期《Cell Stem Cell》杂志上，Duarte 等人（2018）揭示了白血病细胞入侵和占据龛位的时空进展，最终排挤了天然的 HSCs。
