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KIF6 rs20455 多态性与冠心病（CHD）风险的关联：包括 50 项个体研究的汇总分析，共纳入 40059 例病例和 64032 例对照。

Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls.

机构信息

Heart Function Examination Room, the First People's Hospital of Lianyungang, Affiliated Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, 222002, China.

Department of Neurosurgery, the first People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222002, China.

出版信息

Lipids Health Dis. 2018 Jan 5;17(1):4. doi: 10.1186/s12944-017-0651-y.

DOI:10.1186/s12944-017-0651-y
PMID:29304815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5755295/
Abstract

BACKGROUND: The KIF6 rs20455 polymorphism has been verified as an important genetic factor of coronary heart disease (CHD), but with controversial results. The aim of this study was to explore the association between KIF6 rs20455 polymorphism and susceptibility to CHD. METHODS: All eligible studies were identified by searching Medline (mainly PubMed), EMBASE, the Web of Science, Cochrane Collaboration Database, Chinese National Knowledge Infrastructure, Wanfang Database and China Biological Medicine up to October 5, 2016.Odds ratios (ORs) with 95% confidence interval (CI) were used to explore the association between KIF6 rs20455 polymorphism and CHD risk. Begg's and Egger's tests were used to examine the publication bias. Subgroup analysis and sensitivity analysis were performed to test the reliability and stability of the results. All the analyses were carried out by Stata 12.0 software. RESULTS: A total of 28 publications including 50 individual studies were analyzed in this present work. There are no significant association found between KIF6 rs20455 polymorphism and CHD risk (Homozygote model: OR = 1.007, 95% CI =0.952-1.066, P = 0.801; Heterozygote model: OR = 1.009, 95% CI = 0.968-1.052, P = 0.636; Dominant model: OR = 1.007, 95% CI = 0.966-1.048, P = 0.753; Recessive model: OR = 0.989, 95% CI = 0.943-1.037, P = 0.655; Allele comparison model: OR = 1.00, 95% CI = 0.971-1.030, P = 0.988). Furthermore, subgroup analyses were performed by ethnicity, source of control. CONCLUSIONS: Our result suggests that KIF6 rs20455 polymorphism may not be associated with CHD susceptibility. However, additional very well-designed large-scale studies are warranted to confirm our results.

摘要

背景：KIF6 rs20455 多态性已被证实是冠心病（CHD）的重要遗传因素，但结果存在争议。本研究旨在探讨 KIF6 rs20455 多态性与 CHD 易感性之间的关系。

方法：通过检索 Medline（主要为 PubMed）、EMBASE、Web of Science、Cochrane 协作数据库、中国知网、万方数据库和中国生物医学文献数据库，检索截至 2016 年 10 月 5 日的所有相关研究。使用优势比（OR）及其 95%置信区间（CI）来评估 KIF6 rs20455 多态性与 CHD 风险之间的关联。采用 Begg 和 Egger 检验评估发表偏倚。进行亚组分析和敏感性分析以检验结果的可靠性和稳定性。所有分析均采用 Stata 12.0 软件进行。

结果：本研究共纳入 28 篇文献，包括 50 项个体研究。未发现 KIF6 rs20455 多态性与 CHD 风险之间存在显著关联（同型纯合子模型：OR=1.007，95%CI=0.952-1.066，P=0.801；杂合子模型：OR=1.009，95%CI=0.968-1.052，P=0.636；显性模型：OR=1.007，95%CI=0.966-1.048，P=0.753；隐性模型：OR=0.989，95%CI=0.943-1.037，P=0.655；等位基因比较模型：OR=1.00，95%CI=0.971-1.030，P=0.988）。此外，还按种族和对照来源进行了亚组分析。

结论：本研究结果提示 KIF6 rs20455 多态性可能与 CHD 易感性无关。然而，还需要进行更多设计良好的大规模研究来验证我们的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/915d412ab202/12944_2017_651_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/c3ff70e4cf1c/12944_2017_651_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/6e97ae6a4430/12944_2017_651_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/8166ef7dc6a5/12944_2017_651_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/60c2bb4a1181/12944_2017_651_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/c93bc59de186/12944_2017_651_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/f41d67f9e9f7/12944_2017_651_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/7eb57a87143a/12944_2017_651_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/915d412ab202/12944_2017_651_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/c3ff70e4cf1c/12944_2017_651_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/6e97ae6a4430/12944_2017_651_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/8166ef7dc6a5/12944_2017_651_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/60c2bb4a1181/12944_2017_651_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/c93bc59de186/12944_2017_651_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/f41d67f9e9f7/12944_2017_651_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/7eb57a87143a/12944_2017_651_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0695/5755295/915d412ab202/12944_2017_651_Fig8_HTML.jpg

相似文献

[1]
Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls.

Lipids Health Dis. 2018-1-5

[2]
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[3]
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[4]
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[7]
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[8]
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引用本文的文献

[1]
KIF6 gene as a pharmacogenetic marker for lipid-lowering effect in statin treatment.

PLoS One. 2018-10-10

本文引用的文献

[1]
Investigation of KIF6 Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia.

Ann Saudi Med. 2016

[2]
Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men.

Clin Chim Acta. 2016-2-15

[3]
Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.

Arch Iran Med. 2015-10

[4]
Genotyping and meta-analysis of KIF6 Trp719Arg polymorphism in South Indian Coronary Artery Disease patients: A case-control study.

Meta Gene. 2015-7-15

[5]
Novel KIF6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in Han Chinese men.

J Diabetes Res. 2014

[6]
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Lancet. 2014-12-18

[7]
Endothelial nitric oxide synthase gene G894T polymorphism and myocardial infarction: a meta-analysis of 34 studies involving 21,068 subjects.

PLoS One. 2014-1-30

[8]
Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.

PLoS One. 2012-12-7

[9]
Association of KIF6 variant with lipid level and angiographic coronary artery disease events risk in the Han Chinese population.

Molecules. 2012-9-21

[10]
KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.

Atherosclerosis. 2011-12-7

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