NAD(P)H氧化酶p22phox基因（CYBA）中的A640G多态性与冠心病风险降低相关：一项荟萃分析。

The A640G polymorphism in the NAD(P)H oxidase p22phox gene (CYBA) is associated with risk reduction of coronary heart disease: a meta-analysis.

作者信息

Liang Baoyun, Wei Qiugui, Shen Tingting, Su Li, Yan Yan, Wu Guangliang, Lu Jianqi, Gu Lian

机构信息

First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

School of Public Health of Guangxi Medical University, Nanning, Guangxi, China.

出版信息

Clin Biochem. 2014 Apr;47(6):409-16. doi: 10.1016/j.clinbiochem.2013.12.001. Epub 2013 Dec 15.

DOI:10.1016/j.clinbiochem.2013.12.001

PMID:24345348

Abstract

BACKGROUND

Recently, studies have focused on the association between the p22phox gene A640G polymorphism and coronary heart disease (CHD). However, the results are inconsistent. In this study, we aimed to further evaluate this association by using meta-analysis.

METHODS

The PubMed, Embase, CBM, CNKI, WanFang and Chongqing VIP databases were searched for relevant articles. Hardy-Weinberg equilibrium (HWE) of the distribution of genotypes was tested using Pearson's chi-squared test. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were used to assess the strength of the association; Cochran's Q test and the I(2) statistic were used to evaluate heterogeneity. The random effects model and the fixed effects model were used according to heterogeneity; Begg's test and Egger's test were used to analyze publication bias. Sensitivity analysis was carried out to guarantee the stability of the results. Cumulative analysis was used to evaluate tendencies in the pooled OR.

RESULTS

A total of eight articles including 3904 CHD cases and 3498 controls were included. A significant association between the A640G polymorphism and CHD was observed in codominant model 2 (AG versus AA: OR=0.86, 95% CI: 0.77-0.96). In the subgroup analysis, a significant association was observed between the A640G polymorphism and CHD in Caucasians, and in PB (population-based), non-PB, HWE (studies followed HWE) and non-HWE studies.

CONCLUSIONS

Our results reveal that the A640G polymorphism may play a protective role in CHD.

摘要

背景

最近，研究聚焦于p22phox基因A640G多态性与冠心病（CHD）之间的关联。然而，结果并不一致。在本研究中，我们旨在通过荟萃分析进一步评估这种关联。

方法

检索PubMed、Embase、CBM、CNKI、万方和维普数据库中的相关文章。使用Pearson卡方检验对基因型分布进行哈迪-温伯格平衡（HWE）检验。采用比值比（OR）及其相应的95%置信区间（CI）评估关联强度；使用Cochran's Q检验和I(2)统计量评估异质性。根据异质性采用随机效应模型和固定效应模型；使用Begg检验和Egger检验分析发表偏倚。进行敏感性分析以确保结果的稳定性。采用累积分析评估合并OR的趋势。

结果

共纳入8篇文章，包括3904例冠心病病例和3498例对照。在共显性模型2中观察到A640G多态性与冠心病之间存在显著关联（AG与AA相比：OR = 0.86，95%CI：0.77 - 0.96）。在亚组分析中，在白种人以及基于人群（PB）、非PB、符合哈迪-温伯格平衡（HWE，研究遵循HWE）和不符合HWE的研究中，均观察到A640G多态性与冠心病之间存在显著关联。