血清基质金属蛋白酶 3、金属蛋白酶组织抑制因子 3、人附睾蛋白 4 和糖类抗原 125 基线浓度用于卵巢癌患者的适用性评估。
Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer.
机构信息
Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland.
General Pathology Department, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland.
出版信息
J Ovarian Res. 2018 Jan 5;11(1):1. doi: 10.1186/s13048-017-0373-9.
BACKGROUND
MMP and TIMP play an important role in the degradation of extracellular matrix components which are essential for tumor growth, invasion and metastasis. Aim of this research was to assess MMP3 and TIMP3 as prognostic factors among patients with ovarian cancer.
RESULTS
It was found that high levels of output MMP3 correlated with shortened overall survival time of patients by 9.7 months. In addition, it has been shown that high concentrations of output MMP3 were significantly associated with a shorter disease free time in median concentrations implemented p = 0.0059. Statistically significant dependence has been shown between an average concentration of TIMP3 protein to the overall survival of patients. The higher output concentration of TIMP3, the longer patients' survival by 8.9 month. In addition, it was found that high TIMP3 concentrations output were associated with a significantly longer disease free duration at a median concentrations p = 0.007.
CONCLUSION
Preliminary research shows that output levels of MMP3 and TIMP3 proteins correlate with overall survival of patients. In some cases also time free of illness.
背景
MMP 和 TIMP 在细胞外基质成分的降解中发挥重要作用，而细胞外基质成分对于肿瘤的生长、侵袭和转移是必需的。本研究旨在评估 MMP3 和 TIMP3 作为卵巢癌患者的预后因素。
结果
研究发现，高水平的 MMP3 与患者总生存期缩短 9.7 个月相关。此外，研究还表明，输出 MMP3 的高浓度与无病时间缩短显著相关，中位数浓度实施 p = 0.0059。TIMP3 蛋白的平均浓度与患者的总生存期之间存在显著的依赖性。TIMP3 的输出浓度越高，患者的生存时间就越长，为 8.9 个月。此外，研究还发现，TIMP3 浓度较高与无病生存期显著延长相关，中位数浓度 p = 0.007。
结论
初步研究表明，MMP3 和 TIMP3 蛋白的输出水平与患者的总生存期相关。在某些情况下，也与无病时间相关。
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