Rheumatoid Arthritis Pathogenesis Centre of Excellence, Centre for Immunobiology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Centre for Immunobiology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Int Rev Cell Mol Biol. 2018;335:41-84. doi: 10.1016/bs.ircmb.2017.07.007. Epub 2017 Oct 12.
The NF-κB transcription factor was discovered 30 years ago and has since emerged as the master regulator of inflammation and immune homeostasis. It achieves this status by means of the large number of important pro- and antiinflammatory factors under its transcriptional control. NF-κB has a central role in inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and autoimmunity, as well as diseases comprising a significant inflammatory component such as cancer and atherosclerosis. Here, we provide an overview of the studies that form the basis of our understanding of the role of NF-κB subunits and their regulators in controlling inflammation. We also describe the emerging importance of posttranslational modifications of NF-κB in the regulation of inflammation, and highlight the future challenges faced by researchers who aim to target NF-κB transcriptional activity for therapeutic benefit in treating chronic inflammatory diseases.
NF-κB 转录因子于 30 年前被发现，此后已成为炎症和免疫稳态的主要调节剂。它通过其转录控制下的大量重要的促炎和抗炎因子来实现这一地位。NF-κB 在类风湿性关节炎、炎症性肠病和自身免疫等炎症性疾病以及包含炎症成分的疾病（如癌症和动脉粥样硬化）中发挥着核心作用。在这里，我们概述了构成我们对 NF-κB 亚基及其调节剂在控制炎症中作用的理解的研究。我们还描述了 NF-κB 翻译后修饰在炎症调节中的新出现的重要性，并强调了旨在针对 NF-κB 转录活性以治疗慢性炎症性疾病的治疗益处的研究人员所面临的未来挑战。
