原发性甲状腺功能减退症中分泌的小鼠促甲状腺激素唾液酸化和硫酸化的改变。
Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism.
作者信息
DeCherney G S, Gesundheit N, Gyves P W, Showalter C R, Weintraub B D
机构信息
Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892.
出版信息
Biochem Biophys Res Commun. 1989 Mar 15;159(2):755-62. doi: 10.1016/0006-291x(89)90059-4.
We investigated the effect of in vivo hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both alpha and beta subunits. Aging per se had little effect on thyroid-stimulating hormone sialylation or sulfation. Variable sialylation and sulfation demonstrates a mechanism for charge microheterogeneity of thyroid-stimulating hormone, and the increasing sialylation observed with hypothyroidism may functionally mediate the prolonged metabolic clearance that has been noted previously.
我们研究了体内甲状腺功能减退对小鼠垂体外植体分泌的促甲状腺激素（TSH）唾液酸化和硫酸化的影响。来自甲状腺功能减退动物分泌的促甲状腺激素中的寡糖，在α和β亚基中相对于硫酸盐含有更多的唾液酸。衰老本身对促甲状腺激素的唾液酸化或硫酸化影响很小。可变的唾液酸化和硫酸化展示了促甲状腺激素电荷微异质性的一种机制，并且甲状腺功能减退时观察到的唾液酸化增加可能在功能上介导了先前已被注意到的延长的代谢清除。
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