作为抗艾滋病毒药物的2'，3'-二脱氢-2'，3'-二脱氧尿苷、3'-氟-2'，3'-二脱氧尿苷和3'-叠氮基-2'，3'-二脱氧尿苷的5-氯取代衍生物。 - Suppr

Suppr

超能文献

5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.

作者信息

Balzarini J, van Aerschot A, Herdewijn P, de Clercq E

机构信息

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

出版信息

Biochem Pharmacol. 1989 Mar 15;38(6):869-74. doi: 10.1016/0006-2952(89)90273-6.

DOI:10.1016/0006-2952(89)90273-6

PMID:2930588

Abstract

摘要

相似文献

5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.作为抗艾滋病毒药物的2'，3'-二脱氢-2'，3'-二脱氧尿苷、3'-氟-2'，3'-二脱氧尿苷和3'-叠氮基-2'，3'-二脱氧尿苷的5-氯取代衍生物。

Biochem Pharmacol. 1989 Mar 15;38(6):869-74. doi: 10.1016/0006-2952(89)90273-6.

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Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.不同糖修饰的嘧啶和嘌呤核苷的合成及其抗HIV活性

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Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine.5'-异氰基-5'-脱氧胸苷、5'-异氰基-2',5'-二脱氧尿苷、3'-叠氮基-5'-异氰基-3',5'-二脱氧胸苷及3'-叠氮基-5'-异氰基-2',3',5'-三脱氧尿苷的合成与抗逆转录病毒特性

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The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.

Adv Exp Med Biol. 1989;253B:407-13. doi: 10.1007/978-1-4684-5676-9_60.

Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes.

J Biol Chem. 1995 Jun 9;270(23):13660-4. doi: 10.1074/jbc.270.23.13660.

[Inhibition of HIV reproduction in cell culture by 5'-phosphonates of 3'-azido-2',3'-dideoxynucleosides].

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Activities of (-)-carbovir and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.（-）-卡波韦和3'-叠氮-3'-脱氧胸苷在体外对人类免疫缺陷病毒的活性。

Antimicrob Agents Chemother. 1990 Jun;34(6):1297-300. doi: 10.1128/AAC.34.6.1297.

Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate.3'-叠氮-2',3'-双脱氧尿苷的磷酸化及其5'-三磷酸酯对人免疫缺陷病毒和猿猴免疫缺陷病毒逆转录酶的优先抑制作用。

Antimicrob Agents Chemother. 1989 Oct;33(10):1729-34. doi: 10.1128/AAC.33.10.1729.

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Stavudine: a review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection.

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5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile.5-氯-2',3'-二脱氧-3'-氟尿苷（935U83），一种具有改善的代谢和毒理学特性的选择性抗人类免疫缺陷病毒药物。

Antimicrob Agents Chemother. 1994 Jul;38(7):1590-603. doi: 10.1128/AAC.38.7.1590.

Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins.硫酸化多糖和聚合物对各种黏液病毒和逆转录病毒复制的不同抑制作用，取决于病毒包膜糖蛋白靶氨基酸序列的组成。

Antimicrob Agents Chemother. 1991 Dec;35(12):2515-20. doi: 10.1128/AAC.35.12.2515.

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