• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.

作者信息

Balzarini J, van Aerschot A, Herdewijn P, de Clercq E

机构信息

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

出版信息

Biochem Pharmacol. 1989 Mar 15;38(6):869-74. doi: 10.1016/0006-2952(89)90273-6.

DOI:10.1016/0006-2952(89)90273-6
PMID:2930588
Abstract
摘要

相似文献

1
5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.作为抗艾滋病毒药物的2'，3'-二脱氢-2'，3'-二脱氧尿苷、3'-氟-2'，3'-二脱氧尿苷和3'-叠氮基-2'，3'-二脱氧尿苷的5-氯取代衍生物。
Biochem Pharmacol. 1989 Mar 15;38(6):869-74. doi: 10.1016/0006-2952(89)90273-6.
2
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
J Med Chem. 1990 Jan;33(1):258-63. doi: 10.1021/jm00163a043.
3
Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine.
J Med Chem. 1990 Feb;33(2):845-8. doi: 10.1021/jm00164a059.
4
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.不同糖修饰的嘧啶和嘌呤核苷的合成及其抗HIV活性
J Med Chem. 1988 Oct;31(10):2040-8. doi: 10.1021/jm00118a033.
5
Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine.5'-异氰基-5'-脱氧胸苷、5'-异氰基-2',5'-二脱氧尿苷、3'-叠氮基-5'-异氰基-3',5'-二脱氧胸苷及3'-叠氮基-5'-异氰基-2',3',5'-三脱氧尿苷的合成与抗逆转录病毒特性
J Med Chem. 1991 Apr;34(4):1426-30. doi: 10.1021/jm00108a028.
6
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.
Adv Exp Med Biol. 1989;253B:407-13. doi: 10.1007/978-1-4684-5676-9_60.
7
Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes.
J Biol Chem. 1995 Jun 9;270(23):13660-4. doi: 10.1074/jbc.270.23.13660.
8
[Inhibition of HIV reproduction in cell culture by 5'-phosphonates of 3'-azido-2',3'-dideoxynucleosides].
Mol Biol (Mosk). 1989 Nov-Dec;23(6):1716-24.
9
Activities of (-)-carbovir and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.（-）-卡波韦和3'-叠氮-3'-脱氧胸苷在体外对人类免疫缺陷病毒的活性。
Antimicrob Agents Chemother. 1990 Jun;34(6):1297-300. doi: 10.1128/AAC.34.6.1297.
10
Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate.3'-叠氮-2',3'-双脱氧尿苷的磷酸化及其5'-三磷酸酯对人免疫缺陷病毒和猿猴免疫缺陷病毒逆转录酶的优先抑制作用。
Antimicrob Agents Chemother. 1989 Oct;33(10):1729-34. doi: 10.1128/AAC.33.10.1729.

引用本文的文献

1
Toward the development of a virus-cell-based assay for the discovery of novel compounds against human immunodeficiency virus type 1.致力于开发一种基于病毒-细胞的检测方法，用于发现抗1型人类免疫缺陷病毒的新型化合物。
Antimicrob Agents Chemother. 2003 Feb;47(2):501-8. doi: 10.1128/AAC.47.2.501-508.2003.
2
Stavudine: a review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection.
Drugs. 1996 May;51(5):846-64. doi: 10.2165/00003495-199651050-00009.
3
5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile.5-氯-2',3'-二脱氧-3'-氟尿苷（935U83），一种具有改善的代谢和毒理学特性的选择性抗人类免疫缺陷病毒药物。
Antimicrob Agents Chemother. 1994 Jul;38(7):1590-603. doi: 10.1128/AAC.38.7.1590.
4
Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins.硫酸化多糖和聚合物对各种黏液病毒和逆转录病毒复制的不同抑制作用，取决于病毒包膜糖蛋白靶氨基酸序列的组成。
Antimicrob Agents Chemother. 1991 Dec;35(12):2515-20. doi: 10.1128/AAC.35.12.2515.