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The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.

作者信息

Balzarini J, Matthes E, Meeus P, Johns D G, De Clercq E

机构信息

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

出版信息

Adv Exp Med Biol. 1989;253B:407-13. doi: 10.1007/978-1-4684-5676-9_60.

DOI:10.1007/978-1-4684-5676-9_60
PMID:2558542
Abstract
摘要

相似文献

1
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.
Adv Exp Med Biol. 1989;253B:407-13. doi: 10.1007/978-1-4684-5676-9_60.
2
Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.叠氮胸苷及相关的2'，3'-双脱氧核苷对新鲜的和培养的人外周血单核细胞/巨噬细胞中人类免疫缺陷病毒（HIV-1/HTLV-IIIBa-L）复制的抑制作用
J Exp Med. 1988 Sep 1;168(3):1111-25. doi: 10.1084/jem.168.3.1111.
3
Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages.骨髓刺激细胞因子对人免疫缺陷病毒复制及双脱氧核苷在单核细胞/巨噬细胞培养物中的抗病毒活性的影响。
Blood. 1992 Aug 15;80(4):995-1003.
4
Human immunodeficiency virus inhibition is prolonged by 3'-azido-3'-deoxythymidine alternating with 2',3'-dideoxycytidine compared with 3'-azido-3'-deoxythymidine alone.与单独使用3'-叠氮-3'-脱氧胸苷相比，3'-叠氮-3'-脱氧胸苷与2',3'-二脱氧胞苷交替使用可延长对人类免疫缺陷病毒的抑制作用。
Antimicrob Agents Chemother. 1989 Jun;33(6):920-3. doi: 10.1128/AAC.33.6.920.
5
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.2',3'-二脱氢-2',3'-二脱氧核苷对人类免疫缺陷病毒的感染性、细胞病变效应及复制的抑制作用
Antimicrob Agents Chemother. 1987 Jun;31(6):907-10. doi: 10.1128/AAC.31.6.907.
6
Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2',3'-dideoxynucleosides.
Mol Pharmacol. 1994 Oct;46(4):767-72.
7
In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.核苷类似物对人类免疫缺陷病毒的体外骨髓毒性
Antimicrob Agents Chemother. 1989 Apr;33(4):576-9. doi: 10.1128/AAC.33.4.576.
8
5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.作为抗艾滋病毒药物的2'，3'-二脱氢-2'，3'-二脱氧尿苷、3'-氟-2'，3'-二脱氧尿苷和3'-叠氮基-2'，3'-二脱氧尿苷的5-氯取代衍生物。
Biochem Pharmacol. 1989 Mar 15;38(6):869-74. doi: 10.1016/0006-2952(89)90273-6.
9
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.嘌呤和嘧啶衍生物的抗逆转录病毒作用的代谢与机制
Pharm World Sci. 1994 Apr 15;16(2):113-26. doi: 10.1007/BF01880662.
10
[The effect of 3'-azido-3'-deoxynucleosides on the reproduction of AIDS virus in cell culture].
Mol Biol (Mosk). 1988 May-Jun;22(3):802-6.

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Efficacy of antiretroviral agents against murine replication-competent retrovirus infection in human cells.抗逆转录病毒药物对人类细胞中具有复制能力的鼠逆转录病毒感染的疗效。
J Virol. 1999 Oct;73(10):8813-6. doi: 10.1128/JVI.73.10.8813-8816.1999.
2
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.嘌呤和嘧啶衍生物的抗逆转录病毒作用的代谢与机制
Pharm World Sci. 1994 Apr 15;16(2):113-26. doi: 10.1007/BF01880662.
3
Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells.
用于测定外周血单核细胞中三磷酸齐多夫定的酶促测定法。
Antimicrob Agents Chemother. 1994 Jan;38(1):115-21. doi: 10.1128/AAC.38.1.115.
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Zalcitabine. A review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS).扎西他滨。对其在获得性免疫缺陷综合征（艾滋病）中的药理学及临床潜力的综述。
Drugs. 1992 Oct;44(4):656-83. doi: 10.2165/00003495-199244040-00009.