主要类风湿因子交叉反应独特型在青少年类风湿关节炎中的表达
Expression of the major rheumatoid factor cross-reactive idiotype in juvenile rheumatoid arthritis.
作者信息
Ilowite N T, Wedgwood J F, Bonagura V R
机构信息
Division of Allergy/Immunology, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park 11042.
出版信息
Arthritis Rheum. 1989 Mar;32(3):265-70. doi: 10.1002/anr.1780320306.
The major rheumatoid factor cross-reactive idiotype (RF-CRI), defined by prototypic monoclonal IgM rheumatoid factors, is expressed in high frequency by pokeweed mitogen-derived plasma cells from patients with rheumatoid arthritis who express RF in their sera. Unlike adults with rheumatoid arthritis, most patients with juvenile rheumatoid arthritis are seronegative for RF, as detected by classic IgG binding assays. We report that approximately 50% of seronegative patients with juvenile rheumatoid arthritis express the RF-CRI in high frequency among their pokeweed mitogen-derived plasma cells, and that approximately 33% of patients express the RF-CRI in high titer in their sera. The possible mechanisms for expression of an idiotypic marker of RF without expression of IgG binding activity by classic assays are discussed.
由原型单克隆 IgM 类风湿因子定义的主要类风湿因子交叉反应独特型（RF-CRI），在血清中表达 RF 的类风湿关节炎患者的商陆有丝分裂原衍生浆细胞中高频表达。与成年类风湿关节炎患者不同，大多数幼年类风湿关节炎患者通过经典 IgG 结合试验检测显示 RF 血清阴性。我们报告，大约 50% 的血清阴性幼年类风湿关节炎患者在其商陆有丝分裂原衍生浆细胞中高频表达 RF-CRI，并且大约 33% 的患者血清中 RF-CRI 呈高滴度表达。本文讨论了在经典试验中未表现出 IgG 结合活性却表达 RF 独特型标志物的可能机制。
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