用来自青少年关节炎患者的含有IgM类风湿因子的制剂刺激后，正常淋巴细胞产生IgM类风湿因子。
Production of IgM rheumatoid factor by normal lymphocytes after stimulation with preparations containing IgM rheumatoid factor from patients with juvenile arthritis.
作者信息
Nesher G, Moore T L, Osborn T G, Dorner R W
机构信息
Department of Internal Medicine, St Louis University Medical Center, MO.
出版信息
Ann Rheum Dis. 1991 Mar;50(3):142-6. doi: 10.1136/ard.50.3.142.
Preparations containing IgM rheumatoid factor (RF) and hidden IgM RF were isolated from the serum samples of nine patients with juvenile rheumatoid arthritis. Six of these preparations stimulated lymphocytes from normal donors to produce IgG and IgM, of which up to 11% had IgM RF activity. In contrast, the polyclonal activator pokeweed mitogen also stimulated IgM production, but only 1% had IgM RF activity. A relation between the activator and IgM RF or hidden IgM RF is suggested. This is based on the positive correlation between IgM RF concentration in these preparations and their ability to stimulate lymphocytes to produce IgG, IgM, and IgM RF. These data indicate that preparations from patients with juvenile rheumatoid arthritis containing IgM RF and hidden IgM RF are potent stimulants of lymphocytes from normal donors, with specific production of IgM RF.
从9例青少年类风湿性关节炎患者的血清样本中分离出含有IgM类风湿因子（RF）和隐匿性IgM RF的制剂。其中6种制剂刺激正常供体的淋巴细胞产生IgG和IgM，其中高达11%具有IgM RF活性。相比之下，多克隆激活剂商陆有丝分裂原也刺激IgM产生，但只有1%具有IgM RF活性。提示激活剂与IgM RF或隐匿性IgM RF之间存在关联。这是基于这些制剂中IgM RF浓度与其刺激淋巴细胞产生IgG、IgM和IgM RF能力之间的正相关。这些数据表明，来自青少年类风湿性关节炎患者的含有IgM RF和隐匿性IgM RF的制剂是正常供体淋巴细胞的有效刺激剂，可特异性产生IgM RF。
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