Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Neurology, Guangzhou Brain Hospital, China.
J Neuroimmunol. 2018 Feb 15;315:40-44. doi: 10.1016/j.jneuroim.2017.11.016. Epub 2017 Dec 2.
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system whose pathogenesis involves interleukin (IL)-6 and IL-17A. We examined the correlations between CSF concentrations of the acute-phase protein pentraxin 3 (PTX3), the chronic inflammatory mediator CD40L, IL-6, and IL-17A in anti-NMDAR encephalitis, and the impact on clinical outcome. PTX3, CD40L, IL-6, and IL-17A were significantly higher in the CSF of patients with anti-NMDAR encephalitis than in controls. Within the former, PTX3 levels correlated positively with IL-6 and the mRS, and CD40L levels with IL-17A and the mRS. Higher PTX3 and CD40L levels may reflect the underlying neuroinflammation.
抗 N-甲基-D-天冬氨酸受体（NMDAR）脑炎是一种中枢神经系统自身免疫性疾病，其发病机制涉及白细胞介素（IL）-6 和 IL-17A。我们研究了抗 NMDAR 脑炎患者脑脊液中急性期蛋白 pentraxin 3（PTX3）、慢性炎症介质 CD40L、IL-6 和 IL-17A 之间的相关性，以及对临床结局的影响。抗 NMDAR 脑炎患者的 CSF 中 PTX3、CD40L、IL-6 和 IL-17A 明显高于对照组。在前者中，PTX3 水平与 IL-6 和 mRS 呈正相关，CD40L 水平与 IL-17A 和 mRS 呈正相关。较高的 PTX3 和 CD40L 水平可能反映了潜在的神经炎症。
