Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital, Hillerød, North Zealand, Denmark.
Stemform/StemMedical, Cell Production and RnD, Søborg, Copenhagen Region, Denmark.
PLoS One. 2023 Mar 2;18(3):e0282004. doi: 10.1371/journal.pone.0282004. eCollection 2023.
The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.
本研究描述了脑脊液（CSF）Pentraxin 3（PTX3）在中枢神经系统（CNS）感染中的诊断和预后能力。从怀疑患有 CNS 感染的 174 名患者中回顾性测量了 CSF PTX3。计算中位数、ROC 曲线和 Youdens 指数。所有 CNS 感染患者的 CSF PTX3 明显升高，而对照组大多数患者无法检测到，细菌感染患者的 CSF PTX3 明显高于病毒和莱姆感染患者。CSF PTX3 与格拉斯哥结局评分之间无相关性。CSF 中的 PTX3 可区分细菌感染与病毒和莱姆感染以及非 CNS 感染。在细菌性脑膜炎中发现最高水平。未发现预后能力。
