Pascoe Claire, Manning Todd G, Wetherell David, Lawrentschuk Nathan
Department of Urology, Austin Health, Melbourne, Victoria, Australia.
Young Urology Researchers Organisation (YURO), Melbourne, Victoria, Australia.
BMJ Case Rep. 2018 Jan 6;2018:bcr-2017-222480. doi: 10.1136/bcr-2017-222480.
True metastatic ureteric lesions are exceptionally rare when sourced from any primary tumour. Primary prostatic cancer metastasis to the ureter is understandably even more atypical with very few cases reported in current literature. True intramural ureteric metastatic disease deposited from prostate cancer is an even rarer occurrence. We present a case of a man in his mid-60s with left-sided hydronephrosis in the setting of biochemical recurrence of Gleason 9 prostate cancer. Initially misdiagnosed as obstruction secondary to mass effect from a large trigonal lesion, subsequent investigation revealed solid intramural metastatic deposit of prostate primary tumour in the distal ureter. We detail current hypotheses regarding the subsequent pathophysiology of the disease and its common clinical presentations. Our case highlights that prostatic metastasis should be considered as a differential in coexisting prostate cancer and ureteric obstruction despite its low incidence.
真正的转移性输尿管病变无论源自何种原发性肿瘤都极为罕见。前列腺癌转移至输尿管的情况更是不典型,目前文献报道的病例极少。前列腺癌导致的真正的输尿管壁内转移性疾病更是罕见。我们报告一例60多岁男性,在 Gleason 9级前列腺癌生化复发的情况下出现左侧肾积水。最初被误诊为继发于三角区大病变的肿块效应导致的梗阻,后续检查发现前列腺原发性肿瘤在输尿管远端有实性壁内转移灶。我们详细阐述了关于该疾病后续病理生理学及其常见临床表现的当前假说。我们的病例强调,尽管前列腺转移的发生率较低,但在同时存在前列腺癌和输尿管梗阻时,应将其作为鉴别诊断的考虑因素。