1Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology,Shahid Beheshti University of Medical Sciences,1981619573, Tehran,Iran.
2Imam Hossein Hospital,Shahid Beheshti University of Medical Sciences,1981619573, Tehran,Iran.
Br J Nutr. 2018 Feb;119(3):250-258. doi: 10.1017/S0007114517003439. Epub 2018 Jan 8.
This study was conducted to elucidate the effects of decaffeinated green coffee bean extract (GCE) on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome (Mets). Subjects were randomly allocated to consume 400 mg GCE or placebo capsules twice per d for 8 weeks. Both groups were advised to follow an energy balanced diet. After GCE supplementation, systolic blood pressure (SBP) significantly reduced compared with the placebo group (-13·76 (sd 8·48) v. -6·56 (sd 9·58) mmHg, P=0·01). Also, GCE treatment significantly reduced fasting blood glucose (FBS) (-5·15 (sd 60·22) v. 29·42 (sd 40·01) mg/dl (-0·28 (SD 3·34) v. 1·63 (SD 2·22) mmol/l); P=0·03) and homoeostatic model of assessment of insulin resistance in comparison to placebo (-1·41 (sd 3·33) v. 1·23 (sd 3·84), P=0·02). In addition, waist circumference (-2·40 (sd 2·54) v. -0·66 (sd 1·17) cm, P=0·009) and appetite score (-1·44 (sd 1·72) v. -0·2 (sd 1·32), P=0·01) of the individuals supplemented with GCE indicated a significant decline. Besides, weight and BMI reduction in the intervention group was almost twice as much as the placebo group; however, this discrepancy was marginally significant (weight: -2·08 (sd 2·11) v. -0·92 (sd 1·30) kg, P=0·05). No difference was observed in terms of glycated Hb (HbA1c) percentage and lipid profile parameters between the two groups. To sum up, GCE administration had an ameliorating effect on some of the Mets components such as high SBP, high FBS and Mets main aetiological factors including insulin resistance and abdominal obesity. Furthermore, GCE supplementation could reduce appetite level.
这项研究旨在阐明脱咖啡因绿咖啡豆提取物（GCE）对代谢综合征（Mets）患者的人体测量指标、血糖控制、血压、血脂、胰岛素抵抗和食欲的影响。受试者被随机分配，每天服用 400 毫克 GCE 或安慰剂胶囊两次，持续 8 周。两组均被建议遵循能量平衡饮食。GCE 补充后，收缩压（SBP）与安慰剂组相比显著降低（-13.76（sd 8.48）与-6.56（sd 9.58）mmHg，P=0.01）。此外，GCE 治疗还显著降低了空腹血糖（FBS）（-5.15（sd 60.22）与 29.42（sd 40.01）mg/dl（-0.28（SD 3.34）与 1.63（SD 2.22）mmol/l）；P=0.03）和稳态模型评估的胰岛素抵抗与安慰剂相比（-1.41（sd 3.33）与 1.23（sd 3.84），P=0.02）。此外，GCE 补充组的腰围（-2.40（sd 2.54）与-0.66（sd 1.17）cm，P=0.009）和食欲评分（-1.44（sd 1.72）与-0.2（sd 1.32），P=0.01）均显著下降。此外，干预组的体重和 BMI 减轻量几乎是安慰剂组的两倍；然而，这一差异仅具有边缘显著性（体重：-2.08（sd 2.11）与-0.92（sd 1.30）kg，P=0.05）。两组之间糖化血红蛋白（HbA1c）百分比和血脂参数没有差异。总之，GCE 给药对一些 Mets 成分有改善作用，如高血压、高 FBS 和 Mets 的主要病因因素，包括胰岛素抵抗和腹部肥胖。此外，GCE 补充剂可以降低食欲水平。
