绿咖啡提取物补充剂对成年人人体测量学指标的影响：随机临床试验的综合系统评价和剂量反应荟萃分析。
The effect of green coffee extract supplementation on anthropometric measures in adults: A comprehensive systematic review and dose-response meta-analysis of randomized clinical trials.
机构信息
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
出版信息
Complement Ther Med. 2020 Jun;51:102424. doi: 10.1016/j.ctim.2020.102424. Epub 2020 May 5.
BACKGROUND AND AIM
Two meta-analyses summarized data on the effects of green coffee extract (GCE) supplementation on anthropometric measures. However, the accuracy of those meta-analyses is uncertain due to several methodological limitations. Therefore, we aimed to conduct a comprehensive systematic review and dose-response meta-analysis to summarize all available evidence on the effects of GCE supplementation on anthropometric measures by considering the main limitations in the previous meta-analyses.
METHODS
We searched available online databases for relevant publications up to January 2020, using relevant keywords. All randomized clinical trials (RCTs) investigating the effects of GCE supplementation, compared with a control group, on anthropometric measures [including body weight, body mass index (BMI), body fat percentage, waist circumference (WC) and waist-to-hip ratio (WHR)] were included.
RESULTS
After identifying 1871 studies from our initial search, 15 RCTs with a total sample size of 897 participants were included in the systematic review and meta-analysis. We found a significant reducing effect of GCE supplementation on body weight (weighted mean difference (WMD): -1.23, 95 % CI: -1.64, -0.82 kg,P < 0.001), BMI (WMD: -0.48, 95 % CI: -0.78, -0.18 kg/m, P = 0.001), and WC (WMD: -1.00, 95 % CI: -1.70, -0.29 cm, P = 0.006). No significant effect of GCE supplementation on body fat percentage and WHR was seen. In the dose-response analyses, there was no significant association between chlorogenic acid (CGA) dosage, as the main polyphenol in green coffee, and changes in anthropometric measures.
CONCLUSION
We found that GCE supplementation had a beneficial effect on body weight, BMI and WC. It provides a cost-effective and safe alternative for the treatment of obesity. Additional well-designed studies are required to further confirm our findings.
背景和目的
两项荟萃分析总结了绿咖啡提取物（GCE）补充剂对人体测量指标影响的数据。然而，由于存在若干方法学局限性，这些荟萃分析的准确性并不确定。因此，我们旨在进行全面的系统评价和剂量-反应荟萃分析，以总结考虑到之前荟萃分析中的主要局限性后，所有关于 GCE 补充剂对人体测量指标影响的可用证据。
方法
我们使用相关关键词，对截至 2020 年 1 月的在线数据库进行了相关文献的检索。所有将 GCE 补充剂与对照组进行比较，以研究 GCE 补充剂对人体测量指标（包括体重、体重指数（BMI）、体脂肪百分比、腰围（WC）和腰臀比（WHR））影响的随机对照试验（RCT）都被纳入。
结果
从最初的搜索中识别出 1871 项研究后，纳入了 15 项 RCT，共 897 名参与者纳入了系统评价和荟萃分析。我们发现 GCE 补充剂具有显著的减重效果（加权均数差（WMD）：-1.23，95 %置信区间（CI）：-1.64，-0.82 kg，P < 0.001）、BMI（WMD：-0.48，95 % CI：-0.78，-0.18 kg/m，P = 0.001）和 WC（WMD：-1.00，95 % CI：-1.70，-0.29 cm，P = 0.006）。GCE 补充剂对体脂肪百分比和 WHR 没有显著影响。在剂量-反应分析中，绿咖啡中的主要多酚类物质绿原酸（CGA）剂量与人体测量指标的变化之间没有显著关联。
结论
我们发现 GCE 补充剂对体重、BMI 和 WC 有有益的影响。它为肥胖的治疗提供了一种具有成本效益且安全的替代方法。需要进一步进行设计良好的研究来证实我们的发现。
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