Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
Complement Ther Med. 2020 Jun;51:102424. doi: 10.1016/j.ctim.2020.102424. Epub 2020 May 5.
Two meta-analyses summarized data on the effects of green coffee extract (GCE) supplementation on anthropometric measures. However, the accuracy of those meta-analyses is uncertain due to several methodological limitations. Therefore, we aimed to conduct a comprehensive systematic review and dose-response meta-analysis to summarize all available evidence on the effects of GCE supplementation on anthropometric measures by considering the main limitations in the previous meta-analyses.
We searched available online databases for relevant publications up to January 2020, using relevant keywords. All randomized clinical trials (RCTs) investigating the effects of GCE supplementation, compared with a control group, on anthropometric measures [including body weight, body mass index (BMI), body fat percentage, waist circumference (WC) and waist-to-hip ratio (WHR)] were included.
After identifying 1871 studies from our initial search, 15 RCTs with a total sample size of 897 participants were included in the systematic review and meta-analysis. We found a significant reducing effect of GCE supplementation on body weight (weighted mean difference (WMD): -1.23, 95 % CI: -1.64, -0.82 kg,P < 0.001), BMI (WMD: -0.48, 95 % CI: -0.78, -0.18 kg/m, P = 0.001), and WC (WMD: -1.00, 95 % CI: -1.70, -0.29 cm, P = 0.006). No significant effect of GCE supplementation on body fat percentage and WHR was seen. In the dose-response analyses, there was no significant association between chlorogenic acid (CGA) dosage, as the main polyphenol in green coffee, and changes in anthropometric measures.
We found that GCE supplementation had a beneficial effect on body weight, BMI and WC. It provides a cost-effective and safe alternative for the treatment of obesity. Additional well-designed studies are required to further confirm our findings.
两项荟萃分析总结了绿咖啡提取物（GCE）补充剂对人体测量指标影响的数据。然而，由于存在若干方法学局限性，这些荟萃分析的准确性并不确定。因此，我们旨在进行全面的系统评价和剂量-反应荟萃分析，以总结考虑到之前荟萃分析中的主要局限性后，所有关于 GCE 补充剂对人体测量指标影响的可用证据。
我们使用相关关键词，对截至 2020 年 1 月的在线数据库进行了相关文献的检索。所有将 GCE 补充剂与对照组进行比较，以研究 GCE 补充剂对人体测量指标（包括体重、体重指数（BMI）、体脂肪百分比、腰围（WC）和腰臀比（WHR））影响的随机对照试验（RCT）都被纳入。
从最初的搜索中识别出 1871 项研究后，纳入了 15 项 RCT，共 897 名参与者纳入了系统评价和荟萃分析。我们发现 GCE 补充剂具有显著的减重效果（加权均数差（WMD）：-1.23，95 %置信区间（CI）：-1.64，-0.82 kg，P < 0.001）、BMI（WMD：-0.48，95 % CI：-0.78，-0.18 kg/m，P = 0.001）和 WC（WMD：-1.00，95 % CI：-1.70，-0.29 cm，P = 0.006）。GCE 补充剂对体脂肪百分比和 WHR 没有显著影响。在剂量-反应分析中，绿咖啡中的主要多酚类物质绿原酸（CGA）剂量与人体测量指标的变化之间没有显著关联。
我们发现 GCE 补充剂对体重、BMI 和 WC 有有益的影响。它为肥胖的治疗提供了一种具有成本效益且安全的替代方法。需要进一步进行设计良好的研究来证实我们的发现。
