Ildarabadi Azam, Vahid-Dastjerdi Marzieh, Ghorbanpour Mina, Mousavi Ahmad, Meshkani Mehrnoush, Yekaninejad Mirsaeed, Saedisomeolia Ahmad
Department of Nutrition Science, Science and Research Branch, Faculty of Medical Science and Technology, Islamic Azad University, Tehran, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
Osong Public Health Res Perspect. 2024 Dec;15(6):521-532. doi: 10.24171/j.phrp.2024.0187. Epub 2024 Nov 20.
Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in green coffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levels in women with PCOS.
This study was a double-blind randomized clinical trial that included 44 patients with PCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n=22) received 400 mg of green coffee supplements, while the control group (n=22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis.
Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p=0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p=0.013) and triglyceride levels by 6.1 units (p=0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-density lipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention.
Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status.
多囊卵巢综合征（PCOS）是一种影响女性的常见、异质性临床综合征。研究女性体内的氧化应激至关重要，因为它与胰岛素抵抗和内皮功能障碍有关。绿原酸是绿咖啡中发现的一种生物活性成分，有许多已记录的健康益处。本研究旨在评估饮用绿咖啡对PCOS女性对氧磷酶-1（PON-1）活性和丙二醛（MDA）水平的有益影响。
本研究是一项双盲随机临床试验，纳入了44例PCOS患者。参与者被随机分配到干预组或对照组。在为期6周的时间里，干预组（n = 22）服用400毫克绿咖啡补充剂，而对照组（n = 22）服用400毫克淀粉基安慰剂。在为期6周的干预期前后评估人体测量指标、饮食评估和身体活动水平。此外，采集血样进行实验室分析。
补充绿咖啡使PON-1水平提高了3.5个单位，这是一个显著发现（p = 0.038）。此外，摄入绿咖啡补充剂显著降低血胆固醇水平18.8个单位（p = 0.013）和甘油三酯水平6.1个单位（p = 0.053）。然而，干预后MDA、高密度脂蛋白、低密度脂蛋白、空腹血糖、胰岛素或胰岛素抵抗稳态模型评估水平未观察到显著差异。
补充绿咖啡可改变PCOS女性的PON-1活性和胆固醇水平。然而，它对MDA水平或血糖状态没有显著影响。
