铅作业工人的类固醇激素硫酸化作用
Steroid hormone sulphation in lead workers.
作者信息
Apostoli P, Romeo L, Peroni E, Ferioli A, Ferrari S, Pasini F, Aprili F
机构信息
Institute of Occupational Health, University of Verona, Italy.
出版信息
Br J Ind Med. 1989 Mar;46(3):204-8. doi: 10.1136/oem.46.3.204.
The metabolism of steroid hormones has been investigated in 10 workers exposed to lead and in 10 non-exposed subjects to determine whether lead interferes with the first or second phase reactions of steroid hormone biotransformation, or both. In the exposed workers blood lead concentrations (PbB) ranged from 45 to 69 micrograms/100 ml; in the controls PbB was less than 25 micrograms/100 ml. No statistical differences were found for the total amount of the urinary hormone metabolites, but a drop of about 50% was observed for the sulphated portion. It is suggested that lead interferes with the mechanisms of sulphoconjugation through an effect on the cytosol enzymes sulphotransferase and sulphokinase.
对10名接触铅的工人和10名未接触铅的受试者的类固醇激素代谢进行了研究，以确定铅是否会干扰类固醇激素生物转化的第一阶段或第二阶段反应，或两者都会干扰。接触铅的工人血液中的铅浓度（PbB）范围为45至69微克/100毫升；对照组的PbB低于25微克/100毫升。尿激素代谢物的总量未发现统计学差异，但硫酸化部分下降了约50%。有人认为，铅通过对胞浆酶磺基转移酶和硫酸激酶的作用，干扰了硫酸结合的机制。
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