Rades Dirk, Schiff David
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Departments of Neurology, Neurological Surgery and Medicine, University of Virginia, Charlottesville, VA, United States.
Handb Clin Neurol. 2018;149:227-238. doi: 10.1016/B978-0-12-811161-1.00015-3.
Metastases involving the spinal epidural space and cord parenchyma are major sources of neurological impairment and decreased quality of life in cancer patients. Herein we review the clinical manifestations, pathophysiology, importance of early diagnosis and initiation of treatment, and role of fractionated radiotherapy of these disorders.