p53 与生殖。

p53 and reproduction.

机构信息

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.

出版信息

Fertil Steril. 2018 Jan;109(1):39-43. doi: 10.1016/j.fertnstert.2017.11.026.

DOI:10.1016/j.fertnstert.2017.11.026

PMID:29307398

Abstract

Tumor protein 53 (TP53) and its related family of p63 and p73 are tumor suppressor genes that regulate cellular activity to enhance longevity. p53 binds to specific response elements in DNA, modulating the transcription of genes that govern the major defenses against tumor growth. Additional members of the p53 family are involved with male and female germ cell survival. Although the majority of studies have focused on p53 as a tumor suppressor gene, little is known about its function in normal cellular processes. Polymorphisms of TP53 codon 72 that alter activity levels have been studied with respect to implantation in both the murine and human models. TP53 codon 72 (arginine) exhibits higher rates of apoptosis and leukemia inhibitory factor expression, whereas the C allele (proline) reduces leukemia inhibitory factor expression. Here, we review the role of p53 and the family of p53 proteins, along with the potential effect of p53 polymorphisms on reproduction.

摘要

肿瘤蛋白 53（TP53）及其相关的 p63 和 p73 家族是肿瘤抑制基因，它们调节细胞活动以增强寿命。p53 结合到 DNA 中的特定反应元件上，调节控制对抗肿瘤生长的主要防御的基因的转录。p53 家族的其他成员参与男性和女性生殖细胞的存活。尽管大多数研究都集中在 p53 作为肿瘤抑制基因上，但对其在正常细胞过程中的功能知之甚少。已经研究了改变活性水平的 TP53 密码子 72 多态性在鼠和人类模型中的植入情况。TP53 密码子 72（精氨酸）表现出更高的细胞凋亡和白血病抑制因子表达率，而 C 等位基因（脯氨酸）则降低白血病抑制因子表达。在这里，我们回顾了 p53 及其 p53 蛋白家族的作用，以及 p53 多态性对生殖的潜在影响。