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Does platelet serotonin receptor supersensitivity accompany endogenous depression?

作者信息

Brusov O S, Beliaev B S, Katasonov A B, Zlobina G P, Factor M I, Lideman R R

机构信息

Institute of Clinical Psychiatry, All-Union Center for Mental Health of the Academy of Medical Science, Moscow, U.S.S.R.

出版信息

Biol Psychiatry. 1989 Feb 15;25(4):375-81. doi: 10.1016/0006-3223(89)90190-x.

DOI:10.1016/0006-3223(89)90190-x
PMID:2930807
Abstract

In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly (p less than 0.001) lower (0.13 +/- 0.0.04 microM) than that of closely matched controls (0.532 +/- 0.1 microM). This platelet concentration becomes higher after 1-3 months of antidepressant treatment (0.47 +/- 0.16 microM). Possible mechanisms for this up- or down-regulation of platelet serotonin receptor responsiveness are discussed.

摘要

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