重度抑郁症患者血小板中的血清素能标志物：5-HT2受体上调。
Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors.
作者信息
Hrdina P D, Bakish D, Chudzik J, Ravindran A, Lapierre Y D
机构信息
Department of Psychiatry, University of Ottawa, Ontario, Canada.
出版信息
J Psychiatry Neurosci. 1995 Jan;20(1):11-9.
Abstract
The uptake of [3H]5-HT and the density (Bmax) as well as affinity (Kd) of 5-HT uptake sites labelled with [3H]paroxetine and of 5-HT2 receptors labelled by [3H]LSD were determined in platelets from 25 medication-free patients with major depression and 20 normal controls. The density (Bmax) of 5-HT2 receptors was found to be significantly increased (by 52%) in platelets from depressed patients, particularly females. No changes were found in the affinity (Kd) of 5-HT2 receptors and in 5-HT uptake or [3H]paroxetine binding parameters. Density of 5-HT2 receptors positively correlated with that of [3H]paroxetine sites in control but not in depressed subjects. No correlation was found between the HAMD scores and Bmax of [3H]LSD binding. The results suggest that upregulation of platelet 5-HT2 receptors is a useful biological marker in major depression, particularly in females.
摘要
在25名未服用药物的重度抑郁症患者和20名正常对照者的血小板中，测定了[3H]5-羟色胺（5-HT）的摄取以及用[3H]帕罗西汀标记的5-HT摄取位点和用[3H]麦角酸二乙酰胺（LSD）标记的5-HT2受体的密度（Bmax）和亲和力（Kd）。发现抑郁症患者，尤其是女性患者的血小板中5-HT2受体的密度（Bmax）显著增加（增加了52%）。5-HT2受体的亲和力（Kd）、5-HT摄取或[3H]帕罗西汀结合参数均未发现变化。在对照组中，5-HT2受体的密度与[3H]帕罗西汀位点的密度呈正相关，但在抑郁症患者中无此相关性。汉密尔顿抑郁量表（HAMD）评分与[3H]LSD结合的Bmax之间未发现相关性。结果表明，血小板5-HT2受体上调是重度抑郁症，尤其是女性患者中一种有用的生物学标志物。
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