Poland R E, Tondo L, Rubin R T, Trelease R B, Lesser I M
Department of Psychiatry, Harbor-UCLA Medical Center, Torrance 90509.
Biol Psychiatry. 1989 Feb 15;25(4):403-12. doi: 10.1016/0006-3223(89)90193-5.
Scopolamine (SCOP) (3.0 mu/kg and 6.0 micrograms/kg) and saline were administered intramuscularly at 11:00 PM to eight normal male volunteers in a randomized design, and the effects on the sleep electroencephalogram (EEG) and nocturnal cortisol secretion (via blood sampling every 15 min) were evaluated. Compared to saline, SCOP produced a significant dose-related delay in rapid eye movement (REM) latency. In contrast, neither dose of SCOP significantly affected nocturnal plasma cortisol concentrations. These results suggest that the central cholinergic system that regulates the onset of REM sleep is more sensitive to dysregulation than the cholinergic system that controls the degree of nocturnal cortisol secretion. If central cholinergic overactivity is responsible for both the REM sleep latency and cortisol abnormalities in depressed patients, then our findings with SCOP might help explain why the incidences of these abnormalities are different.
在晚上11点，以随机设计对8名正常男性志愿者肌肉注射东莨菪碱（SCOP）（3.0微克/千克和6.0微克/千克）和生理盐水，并评估其对睡眠脑电图（EEG）和夜间皮质醇分泌（通过每15分钟采集一次血样）的影响。与生理盐水相比，SCOP导致快速眼动（REM）潜伏期出现显著的剂量相关延迟。相比之下，两种剂量的SCOP均未显著影响夜间血浆皮质醇浓度。这些结果表明，调节REM睡眠开始的中枢胆碱能系统比控制夜间皮质醇分泌程度的胆碱能系统对失调更敏感。如果中枢胆碱能活动过度是抑郁症患者REM睡眠潜伏期和皮质醇异常的原因，那么我们使用SCOP的研究结果可能有助于解释为什么这些异常的发生率不同。
