School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AP, UK.
Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Cell Tissue Res. 2018 Jul;373(1):39-50. doi: 10.1007/s00441-017-2759-9. Epub 2018 Jan 8.
The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction pathways in which LRRK2 is involved, it has been challenging to generate a clear idea as to how mutations and disease associated variants in this gene are altered in disease. Understanding the events in which LRRK2 is involved at a systems level is therefore critical to fully understand the biology and pathobiology of this protein and is the subject of this review.
LRRK2 基因是帕金森病遗传风险的主要贡献者，了解富含亮氨酸重复激酶 2（LRRK2，该基因的蛋白质产物）的生物学特性是帕金森病研究的重要目标。LRRK2 是一种多功能、多活性酶，与细胞内的多种信号事件有关。由于 LRRK2 参与的信号转导途径非常复杂，因此很难清楚地了解该基因中的突变和与疾病相关的变异在疾病中是如何改变的。因此，从系统水平上了解 LRRK2 所涉及的事件对于充分理解该蛋白的生物学和病理生物学至关重要，也是本综述的主题。
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