Algorithm of Molecular and Biological Assessment of the Mechanisms of Sensitivity to Drug Toxicity by the Example of Cyclophosphamide.

作者信息

Telegin L Yu, Sarmanaev S Kh, Devichenskii V M, Tutelyan V A

机构信息

Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia.

Institute for Advanced Studies, Federal Medical-Biological Agency, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2018 Jan;164(3):324-329. doi: 10.1007/s10517-018-3982-4. Epub 2018 Jan 8.

Comparative study of the liver, blood, and spleen of DBA/2JSto and BALB/cJLacSto mice sensitive and resistant to acute toxicity of the cyclophosphamide allowed us to reveal basic toxicity biomarkers of this antitumor and immunosuppressive agent. Obtained results can be used for the development of an algorithm for evaluation of toxic effects of drugs and food components.