Pevnitsky L A, Zhirnov G F, Mazurov A V, Viktorov V V
Int J Immunopharmacol. 1985;7(6):875-80. doi: 10.1016/0192-0561(85)90050-5.
In one of our previous studies (Pevnitsky et al., Bull. exp. Biol. Med., 83, 438-440, 1977), we have found significant differences between various strains of mice in the sensitivity to immunodepressant action of cyclophosphamide (CP). The degree of these differences was not determined by the level of their immune response which indicates that the cause of the interstrain differences lies in a specific reaction of mice to the immunodepressant. The main parameters of CP effect which may be responsible for variable sensitivity to the immunodepressant action in vivo were studied in several murine strains (Balb/cJLacSto, CBA/CaLacSto, and DBA/2JSto): (1) rate of the preparation activation in liver microsomes; (2) pharmacokinetics of NBP-metabolites in the blood serum; (3) immunodepressant action of the in vivo activated CP; (4) sensitivity of immunocompetent target cells to activated CP effect. It was found that DBA/2 mice are the most sensitive to CP in vivo. The level of "active" CP in their blood serum is higher than in BALB/c mice. Besides, they are characterized by a higher sensitivity of immunocompetent cells compared to BALB/c and CBA mice.
在我们之前的一项研究中（佩夫尼茨基等人，《实验生物学与医学通报》，第83卷，第438 - 440页，1977年），我们发现不同品系的小鼠对环磷酰胺（CP）免疫抑制作用的敏感性存在显著差异。这些差异的程度并非由它们的免疫反应水平决定，这表明品系间差异的原因在于小鼠对免疫抑制剂的特异性反应。在几种小鼠品系（Balb/cJLacSto、CBA/CaLacSto和DBA/2JSto）中研究了可能导致体内对免疫抑制作用敏感性不同的CP效应的主要参数：（1）肝微粒体中制剂的活化速率；（2）血清中NBP - 代谢产物的药代动力学；（3）体内活化的CP的免疫抑制作用；（4）免疫活性靶细胞对活化CP效应的敏感性。结果发现，DBA/2小鼠在体内对CP最为敏感。它们血清中“活性”CP的水平高于BALB/c小鼠。此外，与BALB/c和CBA小鼠相比，它们的免疫活性细胞具有更高的敏感性。
