Lukyanova L D, Kirova Yu I, Germanova E L
Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Bull Exp Biol Med. 2018 Jan;164(3):298-303. doi: 10.1007/s10517-018-3976-2. Epub 2018 Jan 8.
Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.
缺氧诱导大脑皮层中转录因子HIF-1α的即时表达受三羧酸循环和GABA分流反应中产生的琥珀酸调节，并由含琥珀酸的药物诱导。这些事实证明了存在依赖琥珀酸的信号调节，其参与即时和延迟的分子适应以及增强机体对缺氧的耐受性，其中琥珀酸作为信号分子发挥作用。这一过程的强度在对缺氧耐受性低和高的动物中有所不同。
