Jiang Yi, Deng Jie-Dan, Wang Hui-Hong, Zou Jiao-Xia, Wang Yong-Qiang, Chen Jin-Hong, Zhu Long-Qing, Zhang Hong-Hua, Peng Xue, Wang Zhen
School of Pharmacy, Lanzhou University, West Donggang Road. No. 199, Lanzhou 730000, China.
Chem Commun (Camb). 2018 Jan 18;54(7):802-805. doi: 10.1039/c7cc09026a.
An efficient, environmentally benign and unprecedented synthesis of various α-sulfenylated amides/esters has been developed under oxygen atmosphere. The reaction shows good functional group tolerance and excellent chemo/regioselectivity. All the desired products were obtained in moderate to excellent yields, even on the gram scale. Practically, the related α-thiol Weinreb amide can be readily transferred to a series of prospective compounds, and selenium atom can be introduced to the α-sites of the amides in high yields.
在氧气氛围下，已开发出一种高效、环境友好且前所未有的合成各种α-亚磺酰化酰胺/酯的方法。该反应具有良好的官能团耐受性和出色的化学/区域选择性。即使在克级规模下，所有所需产物均以中等至优异的产率获得。实际上，相关的α-硫醇维纳布酰胺可容易地转化为一系列预期化合物，并且硒原子可以高产率引入酰胺的α位。
