Institute of Organic Chemistry, RWTH Aachen University , Landoltweg 1, 52074 Aachen, Germany.
King Abdullah University of Science and Technology (KAUST), KAUST Catalysis Center (KCC) , Thuwal 23955-6900, Saudi Arabia.
Org Lett. 2017 Aug 18;19(16):4255-4258. doi: 10.1021/acs.orglett.7b01905. Epub 2017 Aug 7.
An efficient nickel-catalyzed decarbonylative cyanation reaction which allows the direct functional-group interconversion of readily available esters into the corresponding nitriles was developed. This reaction successfully offers access to structurally diverse nitriles with high efficiency and excellent functional-group tolerance and provides a good alternative to classical synthetic pathways from diazonium salts or organic halide compounds.
发展了一种高效的镍催化脱羰氰化反应，该反应允许通过直接官能团转化，将易得的酯转化为相应的腈。该反应以高收率和优异的官能团容忍性成功地获得了结构多样的腈，为经典的重氮盐或有机卤化物合成途径提供了良好的替代方法。
