Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire.
J Pediatric Infect Dis Soc. 2019 Mar 28;8(1):53-54. doi: 10.1093/jpids/pix102.
The 2017 Stanley A. Plotkin Lecture in Vaccinology was delivered by Professor Peter F. Wright at the Pediatric Academic Societies Annual Meeting in San Francisco, California, in May 2017. The presentation provided an overview of the mucosal immune system as it applies to vaccinology. Specifically, Professor Wright's lecture highlighted the remarkable opportunities for mucosal immunity research afforded by having both topically administered live vaccines and systemically administered inactivated vaccines available for the same pathogen. Using influenza and poliovirus case studies, Professor Wright described the use of live attenuated vaccines for human challenges and discussed how recent technological advancements in immunological assays have ushered in a new era for investigating the correlates of immune protection against wild-type infections at mucosal sites.
2017 年 Stanley A. Plotkin 疫苗学讲座由 Peter F. Wright 教授在加利福尼亚州旧金山举行的儿科学会年会上发表。该演讲概述了黏膜免疫系统在疫苗学中的应用。具体来说，Wright 教授的演讲强调了同时使用局部施用的活疫苗和全身施用的灭活疫苗来研究黏膜免疫的显著机会。Wright 教授使用流感和脊髓灰质炎病毒案例研究，描述了使用减毒活疫苗进行人体挑战，并讨论了免疫测定技术的最新进展如何开创了一个新时代，用于研究针对黏膜部位野生型感染的免疫保护相关性。
