Barišić Anita, Dević Pavlić Sanja, Ostojić Saša, Pereza Nina
Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, 51000 Rijeka, Croatia.
Gene. 2018 Mar 20;647:48-60. doi: 10.1016/j.gene.2018.01.010. Epub 2018 Jan 5.
Matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP) gene polymorphisms have been extensively evaluated as predisposing factors to human reproductive disorders. However, the evidence available is inconsistent. Therefore, we performed a systematic review and meta-analysis to provide the first comprehensive synopsis of case-control studies that investigated the association of MMP and TIMP gene polymorphisms with disorders that influence fertility and pregnancy complications. Literature search was performed using PubMed and Scopus databases. We included 42 case-control studies in the systematic review for the following disorders: adenomyosis, endometriosis, hypertensive disorders of pregnancy, preterm birth and recurrent spontaneous abortion. Although a large number of MMP and TIMP gene polymorphisms were tested, no exclusive and unambiguous risk factors were identified for any of the disorders. The majority of statistically significant associations were confirmed in just one study. Additionally, we performed two meta-analyses for MMP9 rs3918242 polymorphism in endometriosis/adenomyosis and preeclampsia but found no association with either disorder. Considering the modest associations and conflicting results between individual case-control studies, new data is needed for further research of this subject.
基质金属蛋白酶（MMP）和金属蛋白酶组织抑制剂（TIMP）基因多态性已被广泛评估为人类生殖障碍的易感因素。然而，现有证据并不一致。因此，我们进行了一项系统综述和荟萃分析，以首次全面概述病例对照研究，这些研究调查了MMP和TIMP基因多态性与影响生育力和妊娠并发症的疾病之间的关联。使用PubMed和Scopus数据库进行文献检索。我们在系统综述中纳入了42项病例对照研究，涉及以下疾病：子宫腺肌病、子宫内膜异位症、妊娠高血压疾病、早产和复发性自然流产。尽管测试了大量的MMP和TIMP基因多态性，但未为任何一种疾病确定唯一且明确的危险因素。大多数具有统计学意义的关联仅在一项研究中得到证实。此外，我们对子宫内膜异位症/子宫腺肌病和先兆子痫中的MMP9 rs3918242多态性进行了两项荟萃分析，但未发现与任何一种疾病有关联。考虑到个体病例对照研究之间的关联程度有限且结果相互矛盾，需要新的数据来进一步研究该主题。
