Postgraduate Program in Dentistry, Federal University of Maranhão, São Luís CEP 65080-805, Brazil.
Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís CEP 65080-805, Brazil.
Int J Environ Res Public Health. 2024 Jun 6;21(6):739. doi: 10.3390/ijerph21060739.
The hypothesis that physiological changes in women can affect periodontal tissues is the subject of this study, and inflammatory markers such as matrix metalloproteinase-8 can measure susceptibility to inflammation. The study aimed to analyze MMP-8 levels in periodontal sites of postpartum women and women without a history of pregnancy, comparing health parameters and periodontal disease. This is a case-control study with 40 participants, 20 cases (women in the postpartum period) and 20 controls (women without any pregnancy), who underwent clinical periodontal examination and the collection of crevicular gingival fluid. The ELISA test was used to detect MMP-8 levels. Postpartum women had worse periodontal parameters, such as bleeding index on probing, number of sites with CAL ≥ 3, and fewer teeth present. In the group of women without a history of pregnancy, a significantly lower MMP-8 level was observed in healthy sites and a higher one was observed in periodontal pockets ( < 0.01). In contrast, in postpartum women, MMP-8 levels were elevated in both healthy sites and periodontal pockets ( > 0.01). The MMP-8 levels in gingival fluid appear to be related to periodontal clinical parameters and may be a possible marker of enzymatic changes involved in periodontal tissue destruction in postpartum women.
本研究探讨了女性生理变化是否会影响牙周组织这一假说，并以基质金属蛋白酶-8（MMP-8）等炎症标志物来衡量其炎症易感性。该研究旨在分析产后女性和无妊娠史女性牙周部位的 MMP-8 水平，比较健康参数和牙周疾病。这是一项病例对照研究，共纳入 40 名参与者，20 例（产后女性）和 20 例对照（无妊娠史女性），均接受了临床牙周检查和龈沟液采集。采用 ELISA 法检测 MMP-8 水平。产后女性的牙周参数较差，如探诊出血指数、CAL≥3 的位点数和牙齿缺失数。在无妊娠史女性组中，健康部位的 MMP-8 水平显著较低，牙周袋的水平则较高（<0.01）。相比之下，在产后女性中，健康部位和牙周袋的 MMP-8 水平均升高（>0.01）。龈沟液中的 MMP-8 水平似乎与牙周临床参数有关，可能是产后女性牙周组织破坏相关酶变化的潜在标志物。
