Montenegro R, Knuppel R A, Shah D, O'Brien W F
Am J Obstet Gynecol. 1985 Sep 15;153(2):130-4. doi: 10.1016/0002-9378(85)90095-x.
Thirty postpartum preeclamptic patients from the University of South Florida Obstetrical Service were enrolled in a placebo-controlled, randomized, double-blind study to test the effectiveness of ketanserin in lowering the blood pressure. An intravenous bolus of ketanserin resulted in a significant drop in the mean arterial blood pressure. The decrease in the blood pressure could be maintained by a continuous infusion of ketanserin. Hypertension returned after the medication was discontinued. These observations suggest that ketanserin, a selective blocker of type II serotonin receptors, may be effective in acutely reducing elevated postpartum blood pressure in preeclamptic patients, and that serotonin may play a role in the pathogenesis of preeclampsia, but not be important as a mediator in the severity of the disease.
来自南佛罗里达大学产科的30名产后子痫前期患者参加了一项安慰剂对照、随机、双盲研究，以测试酮色林降低血压的有效性。静脉注射一剂酮色林导致平均动脉血压显著下降。通过持续输注酮色林可维持血压下降。停药后高血压复发。这些观察结果表明，酮色林作为一种II型血清素受体的选择性阻滞剂，可能有效急性降低子痫前期患者产后升高的血压，并且血清素可能在子痫前期的发病机制中起作用，但在该疾病的严重程度方面不作为重要的介质。
