聚合物整体膜（PIMs）作为电渗析萃取非甾体抗炎药和高极性酸性药物的支撑物的应用。
Use of Polymer Inclusion Membranes (PIMs) as support for electromembrane extraction of non-steroidal anti-inflammatory drugs and highly polar acidic drugs.
机构信息
Department of Analytical Chemistry, Faculty of Chemistry, University of Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain.
Department of Analytical Chemistry, Faculty of Chemistry, University of Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain.
出版信息
Talanta. 2018 Mar 1;179:601-607. doi: 10.1016/j.talanta.2017.11.066. Epub 2017 Dec 2.
The use of polymer inclusion membranes (PIMs) as support of 1-octanol liquid membrane in electromembrane extraction (EME) procedure is proposed. Synthesis of PIMs were optimized to a composition of 29% (w/w) of cellulose triacetate as base polymer and 71% (w/w) of Aliquat®336 as cationic carrier. Flat PIMs of 25µm thickness and 6mm diameter were used. EME protocol was implemented for the simultaneous extraction of four non-steroidal anti-inflammatory drugs (NSAIDs) (salicylic acid, ketoprofen, naproxen and ibuprofen) and four highly polar acidic drugs (anthranilic acid, nicotinic acid, amoxicillin and hippuric acid). Posterior HPLC separation of the extracted analytes was developed with diode array detection. Recoveries in the 81-34% range were obtained. EME procedure was applied to human urine samples.
提出了将聚合物浸渍膜（PIM）用作电渗析萃取（EME）过程中 1-辛醇液膜支撑的方法。优化了 PIM 的合成，使其组成为 29%（w/w）的三醋酸纤维素作为基础聚合物和 71%（w/w）的 Aliquat®336 作为阳离子载体。使用了厚度为 25μm 且直径为 6mm 的扁平 PIM。实施了 EME 方案，以同时萃取四种非甾体抗炎药（NSAIDs）（水杨酸、酮洛芬、萘普生和布洛芬）和四种高极性酸性药物（邻氨基苯甲酸、烟酸、阿莫西林和马尿酸）。开发了二极管阵列检测的高效液相色谱法对提取的分析物进行分离。回收率在 81-34%范围内。将 EME 程序应用于人尿样。
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