基于纸质的 SERS 测试条，用于定量检测全血中的黏蛋白-1。
A paper-based SERS test strip for quantitative detection of Mucin-1 in whole blood.
机构信息
State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
出版信息
Talanta. 2018 Mar 1;179:9-14. doi: 10.1016/j.talanta.2017.10.038. Epub 2017 Oct 31.
A paper-based SERS test strip combining strengths of paper chip and Raman active substrate was demonstrated to overcome challenges in spectroscopic sensing of complicated samples and realize quantitative detection of disease markers in whole blood. The precisely controlled Au NPs were not only capable of generating condensed hot spots on the fibers, but also enhanced the size exclusion effect of paper, resulting in the novel performance on both SERS detection and sample pretreatment. A biosensor for Mucin-1 is developed by equipping the Au NPs with aptamer. Combining all these merits, this small, cheap and portable test strip might find wide application in clinical diagnosis and health evaluation.
一种基于纸张的 SERS 测试条结合了纸张芯片和拉曼活性衬底的优势，旨在克服复杂样品光谱传感中的挑战，并实现全血中疾病标志物的定量检测。精确控制的 Au NPs 不仅能够在纤维上产生浓缩的热点，而且增强了纸张的排阻效应，从而在 SERS 检测和样品预处理方面具有新颖的性能。通过在 Au NPs 上配备适体，开发了一种用于粘蛋白-1 的生物传感器。结合所有这些优点，这种小巧、廉价、便携式的测试条可能会在临床诊断和健康评估中得到广泛应用。
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