Zhou Xuan, Jin Lian-Jin, Hu Chun-Yang, Chen Meng, Li Ying, Zhang Yue-Shun
Department of Anesthesia, The Affiliated Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China.
Medicine (Baltimore). 2017 Dec;96(48):e8341. doi: 10.1097/MD.0000000000008341.
This study aimed to assess the efficacy and safety of remifentanil as a general anesthetic during cesarean delivery.
Fifty women with singleton pregnancies undergoing cesarean delivery were randomly divided into intervention and control groups, each group containing 25 subjects. Participants in the intervention group received remifentanil (infused at 2 μg/kg/h), whereas subjects in the control group were given dexmedetomidine (infused at 0.4 μg/kg/h). Outcome measurements included mean arterial blood pressure (MAP), heart rate (HR), bispectral index (BIS), Apgar scores at 1 and 5 minutes, and the pH, PCO2, PO2, and base excess (BE) of umbilical venous and arterial blood.
Forty-four participants completed the study. Patients in the intervention group did not experience greater effect and safety than those in the control group (P > .05), although MAP and BIS values decreased significantly immediately before laryngoscopy (P < .05). In addition, BIS values were reduced significantly at the time of skin incision, at uterine incision, and immediately after fetal delivery when compared with baseline values in both groups (P < .01).
This study concluded that remifentanil and dexmedetomidine exhibited similar efficacy and safety during general anesthesia for cesarean delivery.
本研究旨在评估瑞芬太尼作为剖宫产全身麻醉药的有效性和安全性。
50例单胎妊娠行剖宫产的女性被随机分为干预组和对照组，每组25例。干预组参与者接受瑞芬太尼（以2μg/kg/h的速度输注），而对照组受试者给予右美托咪定（以0.4μg/kg/h的速度输注）。观察指标包括平均动脉压（MAP）、心率（HR）、脑电双频指数（BIS）、1分钟和5分钟时的阿氏评分，以及脐静脉血和动脉血的pH值、PCO2、PO2和碱剩余（BE）。
44名参与者完成了研究。干预组患者在效果和安全性方面并不优于对照组（P>0.05），尽管在喉镜检查前MAP和BIS值显著下降（P<0.05）。此外，与两组的基线值相比，在皮肤切开、子宫切开时以及胎儿娩出后即刻，两组的BIS值均显著降低（P<0.01）。
本研究得出结论，在剖宫产全身麻醉期间，瑞芬太尼和右美托咪定表现出相似的有效性和安全性。
