Mandato Vincenzo Dario, Valli Riccardo, Mastrofilippo Valentina, Bisagni Alessandra, Aguzzoli Lorenzo, La Sala Giovanni Battista
Unit of Obstetrics and Gynecology Unit of Pathology Unit of Surgical Gynecologic Oncology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia Unit of Obstetrics and Gynecology, University of Modena e Reggio Emilia, Reggio Emilia, Italy.
Medicine (Baltimore). 2017 Dec;96(48):e8974. doi: 10.1097/MD.0000000000008974.
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm composed of spindled to epithelioid cells with prominent myxoid stroma and inflammatory infiltrate. It has a low but definite malignant potential. However, its management has never been standardized.
We present the first case of uterine IMT laparoscopically treated. Moreover, we reviewed the English literature regarding uterine IMT published between 1987 and June 2017. A total of 72 cases of uterine IMT were included. Clinical and pathological characteristics, treatments and outcomes were recorded.
A total laparoscopic hysterectomy with opportunistic bilateral salpingectomy was performed. Patient is free of disease at 6 months of follow-up.
Uterine IMT may be identified by anaplastic lymphoma kinase overexpression, its prognosis is usually good, complete excision seems to be effective to avoid relapse and mini invasive surgery seems to be effective and safe to treat uterine IMT. However, considering the age of women affected by disease, conservative management, or medical therapy could be taken in account to avoid surgical injuries and to preserve fertility.
炎性肌纤维母细胞瘤（IMT）是一种罕见的间叶性肿瘤，由梭形至上皮样细胞组成，伴有显著的黏液样基质和炎性浸润。其具有低但明确的恶性潜能。然而，其治疗方法从未标准化。
我们报告首例经腹腔镜治疗的子宫IMT病例。此外，我们回顾了1987年至2017年6月间发表的关于子宫IMT的英文文献。共纳入72例子宫IMT病例。记录了临床和病理特征、治疗方法及结果。
实施了全腹腔镜子宫切除术及双侧输卵管切除术。患者在随访6个月时无疾病复发。
子宫IMT可通过间变性淋巴瘤激酶过表达来识别，其预后通常良好，完整切除似乎对避免复发有效，微创手术似乎对治疗子宫IMT有效且安全。然而，考虑到患病女性的年龄，可考虑采取保守治疗或药物治疗以避免手术损伤并保留生育能力。
