Sato Mitsue, Sugimoto Masahiro, Yamamoto Yuko, Saruta Juri, Tsukinoki Keiichi
Nursing Science, Ryotokuji University, Urayasu, Chiba, 279-8567, Japan.
Nursing Science, Human Care Department, Tohto College of Health Sciences, Fukaya, Saitama, 366-0052, Japan.
BMC Oral Health. 2018 Jan 8;18(1):4. doi: 10.1186/s12903-017-0461-7.
Oral functional ability decreases with age, and systemic immunological ability and quality of life can also deteriorate. Continuous moderate whole-body exercise for older people is known to improve oral functional and their immunological abilities. Here, we evaluated the effect of oral exercise as an alternative training method for highly older people who cannot perform whole-body exercises.
Unstimulated whole saliva samples had been collected for three times before training as baseline data and one time after 3 and 6 weeks of training each. Participants were instructed to conduct self-massage; their tongues were used to press their orbicularis oris muscle and buccinators, and instructed to perform bilateral massage of three major glands for facilitating saliva secretion. Medical histories, daily life habits and characteristics were also collected.
Totally 30 participants (84.2 ± 8.5 years) were enrolled. In contrast to previous researches, increase in salivary Immunoglobulin A (IgA) after the training was not observed. Interestingly, hierarchical clustering analyses revealed clear individual variations as two prominent clusters and a strong positive correlation between stimulated saliva flow rate and IgA flow rate, regardless of the continuous oral functional exercise. Only body mass index (BMI) showed significant differences between the two groups (Z = 2.06, P = 0.039, Wilcoxon rank-sum test) among all collected parameters.
Oral functional training limitedly effects on salivary parameters of highly older people. On the other hand, BMI characterized salivary features more than any other parameters, such as the presence of diseases or medication use in these people.
UMIN-CTR Clinical Trial UMIN000028394 on 27/July 2017, retrospectively registered.
口腔功能能力会随着年龄增长而下降，全身免疫能力和生活质量也可能恶化。众所周知，老年人持续进行适度的全身运动可改善口腔功能和免疫能力。在此，我们评估了口腔运动作为无法进行全身运动的高龄者的替代训练方法的效果。
在训练前收集三次未刺激的全唾液样本作为基线数据，并在每次训练3周和6周后各收集一次。指导参与者进行自我按摩；用舌头按压口轮匝肌和颊肌，并指导对三大唾液腺进行双侧按摩以促进唾液分泌。还收集了病史、日常生活习惯和特征。
共纳入30名参与者（84.2±8.5岁）。与之前的研究不同，训练后未观察到唾液免疫球蛋白A（IgA）增加。有趣的是，分层聚类分析显示出明显的个体差异，分为两个显著的聚类，并且无论口腔功能锻炼是否持续，刺激唾液流速与IgA流速之间存在强正相关。在所有收集参数中，只有体重指数（BMI）在两组之间显示出显著差异（Z = 2.06，P = 0.039，Wilcoxon秩和检验）。
口腔功能训练对高龄者的唾液参数影响有限。另一方面，BMI比这些人的任何其他参数（如疾病存在或药物使用情况）更能表征唾液特征。
UMIN-CTR临床试验UMIN000028394，于2017年7月27日进行回顾性注册。
