Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Cold Spring Harb Perspect Med. 2018 Oct 1;8(10):a030494. doi: 10.1101/cshperspect.a030494.
Chemoprevention of prostate cancer aims to reduce the mortality as well as the public burden of overdetection, which increases anxiety, cost, and morbidity related to the disease. The role of 5-α-reductase inhibitors has been well investigated and shown to decrease the risk of prostate cancer. No current evidence exists to encourage the use of nutrients or vitamins as chemopreventive agents. The modulation of inflammation is one of the most promising targets for chemoprevention of prostate cancer.
前列腺癌的化学预防旨在降低过度检测导致的死亡率和公共负担，过度检测会增加疾病相关的焦虑、成本和发病率。5-α-还原酶抑制剂的作用已得到充分研究，已证明其可降低前列腺癌的风险。目前尚无证据表明鼓励使用营养物或维生素作为化学预防剂。炎症的调节是前列腺癌化学预防最有前途的靶点之一。
