Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.
Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA
J Cell Sci. 2018 Jan 8;131(1):jcs203661. doi: 10.1242/jcs.203661.
Tyrosine kinase substrate (Tks) adaptor proteins are considered important regulators of various physiological and/or pathological processes, particularly cell migration and invasion, and cancer progression. These proteins contain PX and SH3 domains, and act as scaffolds, bringing membrane and cellular components in close proximity in structures known as invadopodia or podosomes. Tks proteins, analogous to the related proteins p47, p40 and NoxO1, also facilitate local generation of reactive oxygen species (ROS), which aid in signaling at invadopodia and/or podosomes to promote their activity. As their name suggests, Tks adaptor proteins are substrates for tyrosine kinases, especially Src. In this Cell Science at a Glance article and accompanying poster, we discuss the known structural and functional aspects of Tks adaptor proteins. As the science of Tks proteins is evolving, this article will point out where we stand and what still needs to be explored. We also underscore pathological conditions involving these proteins, providing a basis for future research to develop therapies for treatment of these diseases.
酪氨酸激酶底物（Tks）衔接蛋白被认为是各种生理和/或病理过程的重要调节剂，特别是细胞迁移和侵袭以及癌症进展。这些蛋白质含有 PX 和 SH3 结构域，作为支架，将膜和细胞成分在称为侵袭伪足或足突的结构中紧密靠近。Tks 蛋白类似于相关蛋白 p47、p40 和 NoxO1，也有助于局部产生活性氧（ROS），这有助于在侵袭伪足和/或足突处进行信号转导，以促进其活性。顾名思义，Tks 衔接蛋白是酪氨酸激酶的底物，尤其是Src。在本期《细胞科学一瞥》文章及其配套海报中，我们讨论了 Tks 衔接蛋白的已知结构和功能方面。随着 Tks 蛋白科学的发展，本文将指出我们的立场以及仍需要探索的地方。我们还强调了涉及这些蛋白质的病理状况，为未来的研究提供了基础，以开发治疗这些疾病的疗法。
