Izzicupo Pascal, D'Amico Maria A, Di Blasio Andrea, Napolitano Giorgio, Nakamura Fabio Y, Di Baldassarre Angela, Ghinassi Barbara
Department of Medicine and Aging Science, University "G. d'Annunzio" of Chieti - Pescara, Chieti, Italy.
Front Endocrinol (Lausanne). 2017 Dec 21;8:363. doi: 10.3389/fendo.2017.00363. eCollection 2017.
The purpose of this study is to evaluate the effect of walking-training on the balance between pro- and antiangiogenic signals and on the angiogenic potential in postmenopausal women.
Thirty-four postmenopausal women (56.18 ± 4.24 years) participated in a 13 weeks program of walking-training. Anthropometric measures, vascular endothelial growth factor (VEGF), interleukin (IL)-1α, IL-1β, IL-2, IL-8, IL-10, IL-12p70, tumor necrosis factor-α (TNF-α), C-reactive protein, insulin, IGF-1, cortisol, dehydroepiandrosterone sulfate (DHEA-S), leptin, visfatin, resistin, and adiponectin were evaluated before and after training. Moreover, serum samples were tested for their ability to chemo-attract endothelial cells and to support the formation of capillary-like structures.
After training, the levels of IL-8, TNF-α, leptin, and resistin were significantly lower, levels of DHEA-S and adiponectin increased, serum angiogenic properties improved, whereas no changes in anthropometric parameters or VEGF were detected.
Walking training reduces inflammatory status and leads to a significant improvement in serum angiogenic properties in the absence of modifications in body composition and VEGF level.
本研究旨在评估步行训练对绝经后女性促血管生成信号与抗血管生成信号平衡以及血管生成潜力的影响。
34名绝经后女性（56.18±4.24岁）参加了为期13周的步行训练项目。在训练前后评估人体测量指标、血管内皮生长因子（VEGF）、白细胞介素（IL）-1α、IL-1β、IL-2、IL-8、IL-10、IL-12p70、肿瘤坏死因子-α（TNF-α）、C反应蛋白、胰岛素、胰岛素样生长因子-1（IGF-1）、皮质醇、硫酸脱氢表雄酮（DHEA-S）、瘦素、内脂素、抵抗素和脂联素。此外，检测血清样本趋化吸引内皮细胞以及支持毛细血管样结构形成的能力。
训练后，IL-8、TNF-α、瘦素和抵抗素水平显著降低，DHEA-S和脂联素水平升高，血清血管生成特性改善，而人体测量参数或VEGF未检测到变化。
步行训练可降低炎症状态，并在身体成分和VEGF水平未改变的情况下使血清血管生成特性显著改善。
