Duzova Halil, Gullu Esin, Cicek Guner, Koksal Burcu K, Kayhan Basak, Gullu Abdullah, Sahin Ibrahim
Department of Physiology, Medical School, Inonu University, Malatya, Turkey -
Physical Education and Sports High School, Inonu University, Malatya, Turkey.
J Sports Med Phys Fitness. 2018 Mar;58(3):295-308. doi: 10.23736/S0022-4707.16.06565-8. Epub 2016 Nov 30.
The objectives of this study were to verify effects of step-aerobic exercise (SAE) and jogging-walking exercise (JWE) program on myokines and adipokines levels in overweight sedentary females.
Volunteer subjects (N.=25) were assigned to two exercise groups: steps aerobics and jogging-walking. The exercise program given to them was for five days a week and for twelve weeks period. Serum samples were collected from venous blood before and immediately after Cardio-Respiratory Fitness Test (CRF) by Bruce protocol and stored at -80 °C until they were assayed before 12 weeks exercise program. After 12-weeks training program this procedure was repeated. Serum TNF-α, IL-6, IL-15, IL-17, IL-18, leptin, resistin and adiponectin levels were assayed by ELISA.
Leptin and IL-15 levels were increased whereas resistin levels were decreased after CRF Test in JWE training group following 12-weeks exercise program. TNF-α, IL-15 and IL-18 levels were higher and leptin levels were lower in SAE group than JWE group after 12-weeks exercise period. However, both SAE and JWE did not lead to significant change in serum levels of IL-17, IL-6 and adiponectin levels.
This study has added to existing knowledge that both SAE and JWE may cause weight loss especially in fat mass. But, the effect of SAE and JWE on myokines and adipokines levels may be the different. Further studies are needed to find out clinical importance of these findings.
本研究的目的是验证有氧阶梯运动（SAE）和慢跑-步行运动（JWE）计划对超重久坐女性的肌动蛋白和脂肪因子水平的影响。
将志愿者受试者（N = 25）分为两个运动组：有氧阶梯运动组和慢跑-步行运动组。给予她们的运动计划为每周五天，为期十二周。在通过布鲁斯方案进行心肺适能测试（CRF）之前和之后立即从静脉血中采集血清样本，并储存在-80°C直至在12周运动计划之前进行检测。在12周训练计划之后重复此过程。通过酶联免疫吸附测定法（ELISA）检测血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-15（IL-15）、白细胞介素-17（IL-17）、白细胞介素-18（IL-18）、瘦素、抵抗素和脂联素水平。
在12周运动计划后的JWE训练组中，CRF测试后瘦素和IL-15水平升高，而抵抗素水平降低。在12周运动期后，SAE组的TNF-α、IL-15和IL-18水平高于JWE组，而瘦素水平低于JWE组。然而，SAE和JWE均未导致血清IL-17、IL-6和脂联素水平的显著变化。
本研究增加了现有知识，即SAE和JWE都可能导致体重减轻，尤其是脂肪量的减少。但是，SAE和JWE对肌动蛋白和脂肪因子水平的影响可能不同。需要进一步研究以确定这些发现的临床重要性。
