Nemes Attila, Marton Imelda, Domsik Péter, Kalapos Anita, Pósfai Éva, Modok Szabolcs, Borbényi Zita, Forster Tamás
2nd Department of Medicine and Cardiology Centre, 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
Division of Haematology, 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
Quant Imaging Med Surg. 2017 Dec;7(6):636-640. doi: 10.21037/qims.2017.12.06.
Persistent eosinophilia and eosinophil-mediated single- or multiple-organ damage are typical features of hypereosinophilic syndrome (HES). Theoretically, eosinophilic infiltration of the ascending aortic wall could not be excluded in HES, therefore the present study aimed to test whether HES is associated with abnormalities in aortic elastic properties.
The present study comprised 10 HES patients (mean age: 57.6±10.1 years, 5 males) without known cardiovascular disease, their results were compared to 19 age-, gender- and risk factor-matched controls (59.2±4.2 years, 15 males). Complete two-dimensional Doppler echocardiography with measurement of echocardiographic aortic elastic properties was performed in all HES cases and controls.
Although neither systolic (30.6±3.4 30.1±3.6 mm, P=ns), nor diastolic (28.7±3.6 27.8±3.2 mm, P=ns) aortic diameter differed significantly between HES patients and matched controls, significantly increased aortic stiffness index (11.19±5.65 7.04±2.97, P<0.05) could be demonstrated in HES patients.
Increased aortic stiffness could be demonstrated in HES patients in their early necrotic phase.
持续性嗜酸性粒细胞增多以及嗜酸性粒细胞介导的单器官或多器官损害是高嗜酸性粒细胞综合征（HES）的典型特征。从理论上讲，HES患者不能排除升主动脉壁嗜酸性粒细胞浸润，因此本研究旨在验证HES是否与主动脉弹性特性异常有关。
本研究纳入10例无已知心血管疾病的HES患者（平均年龄：57.6±10.1岁，男性5例），将其结果与19例年龄、性别和危险因素相匹配的对照者（59.2±4.2岁，男性15例）进行比较。对所有HES患者和对照者均进行了完整的二维多普勒超声心动图检查，并测量了超声心动图主动脉弹性特性。
尽管HES患者与匹配对照者之间的主动脉收缩期直径（30.6±3.4对30.1±3.6mm，P=无显著性差异）和舒张期直径（28.7±3.6对27.8±3.2mm，P=无显著性差异）均无显著差异，但HES患者的主动脉僵硬度指数显著升高（11.19±5.65对7.04±2.97，P<0.05）。
在HES患者坏死早期可证实主动脉僵硬度增加。
