Nemes Attila, Geleijnse Marcel L, Forster Tamás, Soliman Osama I I, Ten Cate Folkert J, Csanády Miklós
2nd Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary.
Clin Cardiol. 2008 Jul;31(7):304-9. doi: 10.1002/clc.20252.
The normal human aorta is not a stiff tube but is characterized by elastic properties with a buffering Windkessel function. Aortic stiffening may cause an increase in aortic pulse pressure, left ventricular load, and ultimately left ventricular hypertrophy. This, together with the decreased diastolic transmyocardial pressure gradient interacts with coronary flow and flow reserve. In recent studies, significant correlations between coronary flow reserve and aortic stiffness have been demonstrated in different patient populations. The aim of the present review is to describe the current echocardiographic modalities to measure aortic stiffness and coronary flow reserve and to overview our knowledge about the relationship between aortic stiffness and coronary flow reserve.
正常人体主动脉并非刚性管道，而是具有弹性特性及缓冲风箱功能。主动脉僵硬度增加可能导致主动脉脉压、左心室负荷增加，最终引起左心室肥厚。这与舒张期跨心肌压力梯度降低共同作用，影响冠状动脉血流及血流储备。近期研究表明，在不同患者群体中，冠状动脉血流储备与主动脉僵硬度之间存在显著相关性。本综述旨在描述目前用于测量主动脉僵硬度和冠状动脉血流储备的超声心动图方法，并概述我们对主动脉僵硬度与冠状动脉血流储备之间关系的认识。
