Radice M, Alli C, Avanzini F, Di Tullio M, Mariotti G, Taioli E, Zussino A
G Ital Cardiol. 1985 Apr;15(4):370-4.
Experimental studies on strains of normotensive rats genetically prone to hypertension and investigations on humans with borderline hypertension have shown an early involvement of the heart, mainly consisting in a trend to ventricular hypertrophy. To assess whether such alterations may preceed or follow the elevation of blood pressure, subjects who will develop hypertension, but whose blood pressure is currently normal must be studied. For this reason, we studied by means of M-mode echocardiography 51 normotensive males aged 14-19 years with family history for hypertension (at least one hypertensive parent; SHT). Fifty-five normotensive subjects with both normotensive parents (SNT), matched for sex and age, were the controls. Average values of the following parameters were significantly higher in SHT than in SNT subjects: interventricular septum (5.4 +/- 0.8 versus 4.9 +/- 0.9 mm/m2; p less than 0.01) and posterior wall (5.4 +/- 1.1 versus 5.0 +/- 0.8 mm/m2; p less than 0.05) thickness, left ventricular mass (125.0 +/- 29.1 versus 109.2 +/- 25.4 g/m2; p less than 0.005) and cross sectional area (10.0 +/- 1.8 versus 8.9 +/- 1.6 cm2/m2; p less than 0.005). No significant difference between the two groups was observed in the indexes of left ventricular function. The existence of alterations of cardiac morphology in normotensive adolescents with genetic risk of hypertension shows that the cardiac involvement may preceed the development of high blood pressure.
对具有高血压遗传倾向的正常血压大鼠品系的实验研究以及对临界高血压患者的调查表明，心脏早期受累，主要表现为心室肥厚的趋势。为了评估这种改变是先于还是后于血压升高出现，必须对那些将会发生高血压但目前血压正常的受试者进行研究。因此，我们通过M型超声心动图对51名年龄在14 - 19岁、有高血压家族史（至少有一位高血压父母；SHT）的正常血压男性进行了研究。55名父母血压均正常（SNT）、年龄和性别匹配的正常血压受试者作为对照。以下参数的平均值在SHT组显著高于SNT组：室间隔厚度（5.4±0.8对4.9±0.9mm/m²；p<0.01）和后壁厚度（5.4±1.1对5.0±0.8mm/m²；p<0.05）、左心室质量（125.0±29.1对109.2±25.4g/m²；p<0.005）和横截面积（10.0±1.8对8.9±1.6cm²/m²；p<0.005）。两组在左心室功能指标上未观察到显著差异。具有高血压遗传风险的正常血压青少年存在心脏形态改变，这表明心脏受累可能先于高血压的发生。
