Zhou P
First Affiliated Hospital of Hunan Medical University, Changsha.
Zhonghua Xin Xue Guan Bing Za Zhi. 1990 Oct;18(5):262-4, 318.
To study whether left ventricular mass and function are related to the activity of the sympathetic nerves in progeny of hypertensive parents, LV parameters by echocardiography and plasma catecholamines by HPLC were used in 33 normotensive sons with two hypertensive parents (SHT) and 33 normotensive sons without family history of hypertension (SNT). The results showed that interventricular septum and left ventricular posterior wall thickness, left ventricular mass were significantly greater in SHT group than in the SNT group. No significant difference was found in plasma catecholamines between SNT group and SHT group. But, positive correlation between left ventricular mass and plasma norepinephrine was observed both in SHT group and SNT group. The regression coefficient in SNT was greater than that in SHT. The left ventricular mass and plasma epinephrine were positively correlated in SHT group. These results suggest that cardiac involvement may precede blood pressure elevation in SHT group and the changes of cardiac morphology might show that myocardium is more sensitive to the activity of sympathetic nerves system in SHT than in SNT.
为研究高血压患者后代左心室质量和功能是否与交感神经活动有关，对33名有两位高血压父母的血压正常儿子（SHT）和33名无高血压家族史的血压正常儿子（SNT），采用超声心动图测量左心室参数，并通过高效液相色谱法测定血浆儿茶酚胺。结果显示，SHT组的室间隔和左心室后壁厚度、左心室质量显著大于SNT组。SNT组和SHT组血浆儿茶酚胺无显著差异。但是，SHT组和SNT组的左心室质量与血浆去甲肾上腺素均呈正相关。SNT组的回归系数大于SHT组。SHT组左心室质量与血浆肾上腺素呈正相关。这些结果表明，SHT组心脏受累可能先于血压升高，心脏形态学改变可能表明，与SNT组相比，SHT组心肌对交感神经系统活动更敏感。
