Cherepanov S A, Grinenko N F, Antonova O M, Kurapov P B, Shepeleva I I, Chekhonin V P
N. I. Pirogov National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2018 Jan;164(3):356-361. doi: 10.1007/s10517-018-3989-x. Epub 2018 Jan 8.
The effects of Hedgehog signaling inhibitor (cyclopamine) and activator (Shh) on drug resistance of U251-MG human glioma cells and human astrocyte culture to cisplatin, temozolomide, and doxorubicin were studied. Cyclopamine and Shh modified the drug resistance of U251-MG cells but not of human astrocytes. Experiments with cyclopamine, Shh, and chemical drugs can contribute to detection of the mechanisms of signaling effects on the drug resistance processes, while the experimental data can serve as one of the criteria for choosing individual chemotherapy for patients.
