1 Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
2 Division of Head and Neck Cancer & Communication Sciences, Duke University Medical Center, Durham, North Carolina, USA.
Otolaryngol Head Neck Surg. 2018 May;158(5):934-941. doi: 10.1177/0194599817750372. Epub 2018 Jan 9.
Objective To validate the Otitis Media-6 (OM-6), a parent-proxy quality-of-life (QOL) questionnaire for infants/young children with OM, against other previously validated generic QOL questionnaires. Study Design Multi-institutional cross-sectional study. Setting Twenty-three otolaryngology, pediatric, and family practices across the United States. Subjects and Methods Caregivers of 6- to 24-month-old children with a history of OM completed the OM-6, OM History Form, and Pediatric Quality of Life (PedsQL) Infant Scales survey. Principal components analysis (PCA) examined the underlying factor structure of items on the OM-6, and Cronbach's α measured the internal consistency of items on each factor. Discriminant validity was assessed with receiver operating curves (ROCs). Results Surveys from 1045 patients were analyzed. The overall OM-6 was strongly to moderately correlated with the PedsQL Infant Scales scores (Pearson r = -0.649 for ages 6-12 months and -0.566 for ages 13-24 months). Two underlying constructs, "Behavior and Symptoms" and "Hearing and Speech," emerged from the PCA. Each factor and the overall OM-6 showed excellent internal consistency reliability (each Cronbach's α >0.75). The areas under the curve on the ROC analyses were <0.65 for recurrent and chronic OM using a variety of frequency and chronicity cut-points and definitions. Conclusion The OM-6 measures 2 underlying QOL constructs, Behavior and Symptoms and Hearing/Speech. The overall OM-6 showed acceptably high internal consistency reliability and good construct validity. However, the ability of the OM-6 to identify children who have more severe clinical recurrent or chronic OM vs milder disease was not supported by our analysis.
目的 验证 Otitis Media-6（OM-6），一种用于评估中耳炎患儿生活质量（QOL）的家长代理问卷，其与其他先前验证的通用 QOL 问卷相比具有有效性。 研究设计 多机构横断面研究。 地点 美国 23 家耳鼻喉科、儿科和家庭诊所。 研究对象和方法 有中耳炎病史的 6-24 个月大儿童的照顾者完成了 OM-6、OM 病史表和儿科生活质量（PedsQL）婴儿量表调查。主成分分析（PCA）检查了 OM-6 项目的潜在因素结构，Cronbach's α 衡量了每个因素项目的内部一致性。采用接收者操作曲线（ROC）评估判别有效性。 结果 对 1045 例患者的调查进行了分析。总体 OM-6 与 PedsQL 婴儿量表评分呈强到中度相关（6-12 个月年龄的 Pearson r = -0.649，13-24 个月年龄的 Pearson r = -0.566）。从 PCA 中得出两个潜在结构，“行为和症状”和“听力和言语”。每个因素和总体 OM-6 均显示出极好的内部一致性可靠性（每个 Cronbach's α >0.75）。在 ROC 分析中，使用各种频率和慢性定义和标准，对于复发性和慢性 OM，曲线下面积小于 0.65。 结论 OM-6 衡量了 2 个潜在的 QOL 结构，行为和症状以及听力/言语。总体 OM-6 显示出可接受的高内部一致性可靠性和良好的结构有效性。然而，我们的分析并未支持 OM-6 识别患有更严重临床复发性或慢性 OM 与轻度疾病的儿童的能力。
