Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Am J Trop Med Hyg. 2018 Apr;98(4):1137-1144. doi: 10.4269/ajtmh.17-0280. Epub 2018 Jan 4.
Case reports and pathology series suggest associations of female genital schistosomiasis () with infertility and ectopic pregnancy. Differential geographic distribution of infertility is not explained by analyses of known risk factors. In this cross-sectional multilevel semi-ecologic study, interpolated prevalence maps for and in East Africa were created using data from two open-access Neglected Tropical Diseases Databases. Prevalence was extracted to georeferenced survey sample points for Demographic and Health Surveys for Ethiopia, Kenya, Tanzania, and Uganda for 2000 and 2010. Exploratory spatial analyses showed that infertility was not spatially random and mapped the clustering of infertility and its co-location with schistosomiasis. Multilevel logistic regression analysis demonstrated that women living in high compared with absent locations had significantly higher odds of infertility (2000 odds ratio [OR] = 1.5 [confidence interval = 1.3, 1.8]; 2010 OR = 1.2 [1.1, 1.5]). Women in high compared with high locations had significantly higher odds of infertility (2000 OR 1.4 [1.1, 1.9]; 2010 OR 1.4 [1.1, 1.8]). Living in high compared with absent locations did not affect the odds of infertility. Infertility appears to be associated spatially with .
病例报告和病理学系列研究表明，女性生殖器血吸虫病（）与不孕和宫外孕有关。对不孕的差异地理分布不能用已知的风险因素分析来解释。在这项跨区域多层次半生态学研究中，使用来自两个开放获取的被忽视热带病数据库的数据，为东非的和绘制了插值患病率地图。将患病率提取到埃塞俄比亚、肯尼亚、坦桑尼亚和乌干达的人口与健康调查的地理参考调查样本点，调查时间为 2000 年和 2010 年。探索性空间分析表明，不孕不是空间随机的，并绘制了不孕及其与血吸虫病的共定位聚类图。多水平逻辑回归分析表明，与不存在的相比，生活在高的位置的妇女不孕的几率明显更高（2000 年的优势比[OR] = 1.5 [置信区间= 1.3, 1.8]；2010 年 OR = 1.2 [1.1, 1.5]）。与高相比，生活在高的位置的妇女不孕的几率明显更高（2000 年 OR 1.4 [1.1, 1.9]；2010 年 OR 1.4 [1.1, 1.8]）。与不存在相比，生活在高的位置并不影响不孕的几率。不孕似乎与有关。
