Sivas Numune Hospital.
Kardiol Pol. 2018;76(4):783-790. doi: 10.5603/KP.2018.0007. Epub 2018 Jan 9.
Serglycin plays a key role in the inflammatory status however the relationship between coronary artery disease (CAD) and serglycin is still unknown.
In this study, we aimed to investigate association of serglycin levels with CAD severity in patients with stable angina pectoris (SAP).
In total, 100 SAP patients diagnosed by coronary angiography and clinical manifestations, and 100 control subjects matched for age and sex were enrolled in this case-control study. Plasma levels of serglycin, high-sensitivity C-reactive protein (hsCRP), lipid profiles, and clinical parameters were assayed for all participants. The severity of coronary lesions was evaluated based on the SYNTAX score (SS) assessed by coronary angiography.
Positively correlated with the SS (r = 0.564, p < 0.001), the plasma serglycin level in the SAP group was higher than that in the control group (11.17 ± 1.82 vs. 19.28 ± 1.88 ng/mL, p < 0.001). The plasma serglycin level was an inde-pendent predictor for both SAP (odds ratio [OR] 1.037, 95% confidence interval [CI] 1.020-1.054, p < 0.001) and a high SS (OR = 1.087, 95% CI 1.051-1.124, p < 0.001) in a multivariate logistic regression model. In the receiver operating characteristic curve analysis, the plasma serglycin level was found to have a better predictive value for a high SS (area under the curve [AUC] 0.858, 95% CI 0.788-0.929, p < 0.001) compared with hsCRP (AUC 0.665, 95% CI 0.557-0.773, p = 0.006; Z = 2.94, p < 0.001), with an optimal cut-off value of 17.25 ng/mL (sensitivity 94.3%, specificity 68.2%).
Plasma serglycin levels correlate with both the presence and severity of coronary stenosis in patients with SAP, suggesting that it could be a potential predictive marker of severe stenosis in SAP patients.
Serglycin 在炎症状态中起着关键作用，但冠状动脉疾病 (CAD) 与 Serglycin 之间的关系尚不清楚。
本研究旨在探讨稳定型心绞痛 (SAP) 患者中 Serglycin 水平与 CAD 严重程度的关系。
本病例对照研究共纳入 100 例经冠状动脉造影和临床表现诊断为 SAP 的患者和 100 例年龄和性别相匹配的对照者。所有参与者均检测血浆 Serglycin、高敏 C 反应蛋白 (hsCRP)、血脂谱和临床参数。根据冠状动脉造影评估的 SYNTAX 评分 (SS) 评估冠状动脉病变严重程度。
Serglycin 水平与 SS 呈正相关(r = 0.564，p < 0.001)，SAP 组的血浆 Serglycin 水平高于对照组(11.17 ± 1.82 vs. 19.28 ± 1.88 ng/mL，p < 0.001)。血浆 Serglycin 水平是 SAP 的独立预测因子(比值比 [OR] 1.037，95%置信区间 [CI] 1.020-1.054，p < 0.001)和高 SS 的独立预测因子(OR = 1.087，95% CI 1.051-1.124，p < 0.001)在多变量逻辑回归模型中。在受试者工作特征曲线分析中，与 hsCRP 相比，血浆 Serglycin 水平对高 SS 的预测价值更好(AUC 0.858，95%CI 0.788-0.929，p < 0.001)，AUC 0.665，95%CI 0.557-0.773，p = 0.006；Z = 2.94，p < 0.001)，最佳截断值为 17.25 ng/mL(敏感性 94.3%，特异性 68.2%)。
血浆 Serglycin 水平与 SAP 患者冠状动脉狭窄的存在和严重程度相关，提示其可能是 SAP 患者严重狭窄的潜在预测标志物。
